Survival Comes at a Cost: A Coevolution of Phage and Its Host Leads to Phage Resistance and Antibiotic Sensitivity of Pseudomonas aeruginosa Multidrug Resistant Strains [PDF]
Frontiers in Microbiology, 2021 The increasing ineffectiveness of traditional antibiotics and the rise of multidrug resistant (MDR) bacteria have necessitated the revival of bacteriophage (phage) therapy. However, bacteria might also evolve resistance against phages.
Sarshad Koderi Valappil +15 more
doaj +5 more sources
Assessing the practicality of using freely available AI-based GPT tools for coach learning and athlete development [PDF]
Frontiers in Sports and Active LivingThis study represents one of the initial efforts to analyse a coach-athlete conversational dataset using freely available GPT tools and a pre-determined, context-specific, prompt-based analyses framework (i.e., R2-PIASS).
Katherine A. O'Brien, Sarah Prentice
doaj +2 more sources
Design a variety of cation exchange hydrogel resins using gamma irradiation to remove hard/scale metal cations from saline water under different circumstances [PDF]
Scientific ReportsThis study aims to develop a series of cation exchange hydrogel resins via gamma irradiation technique through copolymerizing styrene sodium sulfonate with three acrylamide derivatives (designated as poly(X-co-styrene sodium sulfonate), where X refers to
Sherif A. F. Romeeh +5 more
doaj +2 more sources
Age-associated myeloid malignancies - the role of STAT3 and STAT5 in myelodysplastic syndrome and acute myeloid leukemia. [PDF]
FEBS LettThe increase in the aging population has resulted in the rise of age‐related disorders, including MDS and AML. The JAK–STAT pathway is essential for several cellular functions in the HSPCs. Deregulation of the STAT3/5 signaling may occur at several pathway stages (indicated by exclamation points) and has been associated with MDS and AML development ...
Fasouli ES, Katsantoni E.
europepmc +2 more sources
SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability [PDF]
Cell Communication and Signaling, 2019 Background Abnormal reactivation of androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) mainly results from overexpression and down-regulation of AR. Sumoylation of AR can influence its function.
Nanyang Yang +7 more
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Constitutive activation of the EGFR-STAT1 axis increases proliferation of meningioma tumor cells. [PDF]
Neurooncol Adv, 2020 Background: Meningiomas are the most frequent primary brain tumors of the central nervous system. The standard of treatment is surgery and radiotherapy, but effective pharmacological options are not available yet.
Ferluga S +8 more
europepmc +4 more sources
A novel role of Krüppel-like factor 8 in DNA repair in breast cancer cells. [PDF]
J Biol Chem, 2012 Kruppel-like factor 8 (KLF8) regulates critical gene transcription and cellular events associated with cancer. However, the role of KLF8 in cancer remains largely unknown.
Lu H +9 more
europepmc +3 more sources
1. O PROGRAMA DE INTERIORIZAÇÃO DAS AÇÕES DE SAÚDE E SANEAMENTO (PIASS) E A SAÚDE DO NORDESTE [PDF]
Revista Brasileira de Enfermagem, 1976 doaj +3 more sources
Discover Sustainability, 2023 Degradation exacerbates food and water insecurity, economic hardship, biodiversity loss, and the devastating effects of climate change. Given that ecosystem restoration is a global challenge, the United Nations declared 2021 to 2030 as the Decade of ...
Leonidas Maniraho +3 more
doaj +1 more source
Brazilian Journal of Biology, 2022 In current study, different feeding levels of Moringa oleifera formulated diet was compared to analyze the growth performance, feed conversion ratio, feed conversion efficiency and gut microbiology of Oreochromis niloticus.
M. U. Taj +10 more
doaj +1 more source