Results 191 to 200 of about 13,782 (258)

Ruptured Posterior Inferior Cerebellar Artery Aneurysm Presenting With Cerebellar Intraparenchymal and Intraventricular Hemorrhage: A Case Report. [PDF]

Cureus
Obien ECF, Pua PJL, Maglinao AD, Lokin JK, Lagamayo PDJ.   +4 more
europepmc   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

A corona-like distribution and patchy pattern of cerebellar infarcts identify patients with giant cell arteritis. [PDF]

Ther Adv Neurol Disord
Beuker C, Strecker JK, Jungmann V, Werring N, Brix T, Thomas C, Wankner MC, Schmidt-Pogoda A, Stracke P, Eckert B, Meinel TR, Arnold M, Schaumberg J, Krüger S, Deb-Chatterji M, Krüger C, Magnus T, Röther J, Minnerup J.   +18 more
europepmc   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Staged coiling and flow diversion for a ruptured persistent primitive hypoglossal artery aneurysm: illustrative case. [PDF]

J Neurosurg Case Lessons
Goda R, Hayashi H, Nakayasu S, Imanishi K, Maeda M, Murai N.   +5 more
europepmc   +1 more source

Extremely Late Local Recurrence of a Choroidal Melanoma, 51 Years Following Cobalt-60 Plaque Radiation Therapy. [PDF]

Klin Monbl Augenheilkd
Verdon GD, Schalenbourg A, Pica A.
europepmc   +1 more source

Reciprocal association between neurovascular conflict and trigeminal neuralgia: a systematic review and meta-analysis. [PDF]

J Oral Facial Pain Headache
Golubevas R, Buškus A, Janužis G, Razukevičius D, Rokicki JP.   +4 more
europepmc   +1 more source

Case Report: From behavioral disorder to surgical emergency: a case of intussusception due to pica in an adolescent. [PDF]

Front Psychiatry
Alhaj MA, Ahmed MH, Jalkhi T, Armouche R, Alrushdi MA, Elmaghraby H.   +5 more
europepmc   +1 more source

Internal trapping for ruptured vertebral artery dissection involving the anterior spinal artery: A case report. [PDF]

Radiol Case Rep
Tanabe D, Fujita A, Inoue S, Kurihara E, Sasayama T.   +4 more
europepmc   +1 more source