Results 41 to 50 of about 1,452 (183)

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Raman Spectroscopy–Based Glucose Feed Control Automates Malic Acid Fermentation

Biotechnology and Bioengineering, EarlyView.
Raman spectroscopy enables automated, closed‐loop glucose feeding for malic acid production with Ustilago trichophora. Online PLS regression of glucose and malic acid provides input for PID control to maintain 20 g/L glucose. The feed is dynamically adjusted and stopped in response to metabolic demand and product inhibition, demonstrating practical ...
Luca Antonia Grebe, Katharina Hürter, Dominik Engel, Alexander Walter Wilhelm Echtermeyer, Mafalda S. Santos, Laurin Röder, Valentin Steier, Jörn Viell, Jørgen Barsett Magnus   +8 more
wiley   +1 more source

Convergence analysis for Suzuki's generalized nonexpansive mappings [PDF]

Mathematica Moravica, 2023
In this paper, we study the Picard-Mann hybrid iteration process to approximate fixed points of Suzuki's generalized nonexpansive mappings. We establish some weak and strong convergence theorems for such mappings in uniformly convex Banach space.
Ghiura Adrian
doaj  

A review of the historic and present ecological role of aquatic and shoreline wood, from forest to deep sea

Biological Reviews, EarlyView.
ABSTRACT The ecology of forests, their losses, and terrestrial wood decomposition dynamics have been intensively studied and reviewed. In the aquatic realm, reviews have concentrated on large wood (LW) in rivers and the transition from freshwater to marine environments in the Pacific Northwest of North America. However, a comprehensive global synthesis
Jon Dickson, Ellen Wohl, Laura L. Govers, Oscar Franken, Tjeerd J. Bouma, Han Olff, Britas Klemens Eriksson, Maryann S. Watson, Luísa M.S. Borges, Tjisse van der Heide   +9 more
wiley   +1 more source

Reporting What Matters, or Reporting What Looks Good? Materiality and Balance in Post–Rana Plaza Apparel Sustainability Disclosure

Business Strategy and the Environment, EarlyView.
ABSTRACT Sustainability reports (SRs) are widely criticized for vague disclosures and selective emphasis on positive outcomes, yet systematic research on two core SR challenges remains limited: materiality (whether disclosed content is relevant) and balance (whether both achievements and challenges are reported).
Mahsa Mohammadrezaei, José Carlos Marques   +1 more
wiley   +1 more source

Power bounded prolongations and Picard-Lindel�f iteration

Numerische Mathematik, 1990
The author continues several earlier studies of Picard-Lindelöf iteration of linear constant coefficient systems \(\dot x+Ax=f(t),\) \(x(0)=x_ 0\), where the matrix A is assumed to be split as \(A=M-N\) for iteration \(\dot x^ n+Mx^ n=Nx^{n-1}+f(t),\) \(x^ n(0)=x_ 0\) [see e.g. the author, ibid. 57, No.2, 147-156 (1990; Zbl 0697.65058)].
openaire   +2 more sources

Invariant Measure and Universality of the 2D Yang–Mills Langevin Dynamic

Communications on Pure and Applied Mathematics, EarlyView.
ABSTRACT We prove that the Yang–Mills (YM) measure for the trivial principal bundle over the two‐dimensional torus, with any connected, compact structure group, is invariant for the associated renormalised Langevin dynamic. Our argument relies on a combination of regularity structures, lattice gauge‐fixing and Bourgain's method for invariant measures ...
Ilya Chevyrev, Hao Shen
wiley   +1 more source

Coupled Clustering in Hierarchical Matrices for the Oseen Problem

International Journal for Numerical Methods in Fluids, EarlyView.
Fluid flow problems can be modelled by the Navier‐Stokes or, after linearization, by the Oseen equations. Their discretization results in linear systems in saddle point form which are typically very large and need to be solved iteratively. We propose a novel block structure for hierarchical matrices which is then used to build preconditioners for the ...
Jonas Grams, Sabine Le Borne
wiley   +1 more source