Results 41 to 50 of about 190,455 (220)

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Stability Analysis of Picard Iteration for Coupled Neutronics/Thermal-Hydraulics Simulations [PDF]

, 2023
In this paper, we present a formal Fourier analysis (FA) of Picard iteration for the coupled neutronics/thermal hydraulics (N/TH) problem and derive theoretical predictions for the spectral radius of Picard iteration for such coupled calculations as a ...
Wang, Dean
core   +1 more source

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

Advanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan, Hong‐feng Zheng, Mu‐chen Li, Jia‐lin Zhou, Hang‐biao Zhang, Dong‐hao Lyu, Yi‐fan Tang, Tian‐yue Yang, Yi‐fan Liu, Zi‐chang Liu, Wen‐jie Ma, Yuan‐bo Zong, Jian‐gui Liu, Zi‐xuan Gong, Hao Zhang, Ke‐qin Dong, Wang Zhou, Jian‐qin Ye, Xin‐gang Cui   +18 more
wiley   +1 more source

Wardowski conditions to the coincidence problem

Frontiers in Applied Mathematics and Statistics, 2015
In this article we □rst discuss the existence and uniqueness of a solution for the coincidence problem:Find $p in X$ such that Tp = Sp; where X is a nonempty set, Y is a complete metric space, and$T; S : X to Y$ are two mappings satisfying a Wardowski ...
David eAriza-Ruiz, Jesus eGarcia-Falset, Kishin eSadarangani   +2 more
doaj   +1 more source

General Local Convergence Theorems about the Picard Iteration in Arbitrary Normed Fields with Applications to Super–Halley Method for Multiple Polynomial Zeros

Mathematics, 2020
In this paper, we prove two general convergence theorems with error estimates that give sufficient conditions to guarantee the local convergence of the Picard iteration in arbitrary normed fields. Thus, we provide a unified approach for investigating the
Stoil I. Ivanov
doaj   +1 more source

Integration of the D‐Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability

Advanced Science, EarlyView.
Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu, Tao Zhu, Ziru Zhou, Wei Chen, Chao He, Xinkai Zhou, Xin Wang, Chuanye Chen, Bo Yang, Jiaqi Wei, Caixia Lan, Mengmeng Liu, Handong Su, Qiang Li, Xin Hu, Siteng Bi, Weizhi Ouyang, Xingwang Li, Hailiang Mao, Masahiro Kishi, Kerstin Kaufmann, Alisdair R. Fernie, Dijun Chen, Wenhao Yan   +23 more
wiley   +1 more source

Cable Reinforcement Combined With Biologic Tuberoplasty Restores Muscle Forces and Scapular Strain in an Irreparable Rotator Cuff Tear Model: A Cadaveric Study

Arthroscopy, EarlyView.
Purpose To investigate the biomechanical impact of an irreparable rotator cuff tear and compare the isolated and combined effects of rotator cable reconstruction (CR) and biologic tuberoplasty (BioTB). Methods Eight cadaveric shoulders were tested using an ex vivo dynamic shoulder simulator in forward flexion (FF) and scapular plane abduction (SPA ...
Mohammad Haddara, Natalie Guggenbach, Kevin Sun, Maria Antonia Rosanna Pena, Justine Fleurette, Janos Tomka, Desmond Bokor, Manik Dham, Christopher Adams, Richard Appleyard, Sumit Raniga   +10 more
wiley   +1 more source

Reporting What Matters, or Reporting What Looks Good? Materiality and Balance in Post–Rana Plaza Apparel Sustainability Disclosure

Business Strategy and the Environment, EarlyView.
ABSTRACT Sustainability reports (SRs) are widely criticized for vague disclosures and selective emphasis on positive outcomes, yet systematic research on two core SR challenges remains limited: materiality (whether disclosed content is relevant) and balance (whether both achievements and challenges are reported).
Mahsa Mohammadrezaei, José Carlos Marques   +1 more
wiley   +1 more source

The determination of orbits using Picard iteration [PDF]

, 1975
The determination of orbits by using Picard iteration is reported. This is a direct extension of the classical method of Picard that has been used in finding approximate solutions of nonlinear differential equations for a variety of problems.
Feagin, T., Mikkilineni, R. P.
core  

Coupled heat and mass transfer in reactive parallel‐plate flow: A perturbative Graetz model with modal symmetry and Arrhenius kinetics

The Canadian Journal of Chemical Engineering, EarlyView.
A perturbative Graetz model describes coupled heat and mass transfer in reactive Couette–Poiseuille flow between parallel plates. Viscous dissipation and heat of reaction produce a small temperature rise, which enhances Arrhenius reaction rates and modestly accelerates axial species conversion in the small‐Brinkman‐number regime.
Leonardo Damián Soria Rodríguez, Anthony Albert Harrup Gutiérrez   +1 more
wiley   +1 more source