Results 21 to 30 of about 275 (229)

An Integrated Metaheuristic Routing Method for Multiple-Block Warehouses with Ultranarrow Aisles and Access Restriction

Complexity, 2019
A problem-specific routing algorithm integrating ant colony optimization (ACO) and integer-coded genetic algorithm (GA) is developed to address the newly observed limitations imposed by ultranarrow aisles and access restriction, which exist in the ...
Fangyu Chen, Gangyan Xu, Yongchang Wei
doaj   +1 more source

Optimizing order picking processes in warehouses: strategies for efficient routing and clustering

Journal of Modern Science
The study employed a simulation based on a detailed dataset containing over 307,046 unique order identifiers and 1,050 unique product identifiers. This dataset included information such as order placement dates, product codes, quantities, and precise ...
Paweł Rymarczyk, Sylwester Bogacki, Cezary Figura, Marek Rutkowski, Piotr Staliński   +4 more
doaj   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Picker Routing and Batching in Multi-Block Parallel-Aisle Warehouses: An Application from the Logistics Service Provider

Logistics
Background: In today’s business world, where competition lies between supply chains, customer expectations are changing dynamically. Effective order picking in warehouses has become a top concern given expectations for rapid delivery, a larger product ...
Ali Görener
doaj   +1 more source

Sistema de apoio à decisão para a otimização da roteirização da separação manual de peças em armazém utilizando planilhas eletrônicas The order-picking routing problem for low-level order picker in a warehouse

Gestão & Produção, 2011
O presente trabalho trata do problema da determinação de rota de separação manual de peças em armazéns que minimize a distância total percorrida pelo separador.
Antonio Carlos Bonassa, Claudio Barbieri da Cunha   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

An exact analysis and comparison of manual picker routing heuristics

Queueing Systems
AbstractThis paper presents exact derivations of the first two moments of the total order picking time in a warehouse for three routing heuristics, under the assumption of random storage. The analysis is done for general order size distributions and provides exact closed expressions in terms of the probability generating function of the order size ...
Tim Engels, Ivo Adan, Onno J. Boxma, Jacques Resing   +3 more
openaire   +3 more sources