Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Osteoporosis is a metabolic bone disorder that tortures about millions of people worldwide. Recent study demonstrated agents derived from picrasma quassioides is a promising drug for targets multiple signaling pathways.
Lingbo Kong +7 more
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β-Carboline alkaloids from Picrasma quassioides [PDF]
Phytochemistry, 1990 Abstract A new β-carboline alkaloid, picrasidine V, was isolated from the root wood of Picrasma quassioides . The structure was determined as 8-methoxy-1,2,3,4-tetrahydro-1,3,4-trioxo-β-carboline by spectral evidence.
Kazuo Koike, Taichi Ohmoto, Keiji Ikeda
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Corrigendum: Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides’ Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometer Combined With Fragmentation and Retention Time Calculation [PDF]
Frontiers in Pharmacology, 2022 Haibo Hu +8 more
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Picrasidine-U, dimeric alkaloid from Picrasma quassioides [PDF]
Phytochemistry, 1988 Abstract A new canthin-5,6-dione and β-carboline dimeric alkaloid, picrasidine-U was isolated from the root wood of Picrasma quassioides. The structure was determined by spectral analysis and chemical evidence.
Kazuo Koike, Taichi Ohmoto
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Picrasidine S Induces cGAS-Mediated Cellular Immune Response as a Novel Vaccine Adjuvant. [PDF]
Adv Sci (Weinh)This study performs a comprehensive chemical screening of 6800 small molecules and identifies picrasidine S (PS) as a potent IFN‐I inducer. PS acts as a powerful adjuvant, significantly enhancing both humoral and cellular immune responses. It activates the cGAS‐IFN‐I pathway, leading to an increase in CD8+ central memory (TCM)‐like cells and improves ...
Ding X +8 more
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Frontiers in ChemistryChromobacterium violaceum an opportunistic human pathogenic bacterium, exhibits resistance to conventional antibiotics by exploiting its quorum sensing mechanism to regulate virulence factor expression.
Gehan M Elossaily +2 more
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Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from Picrasma quassioides, Inhibits Metastasis of Head and Neck Squamous Cell Carcinoma. [PDF]
Int J Mol Sci, 2023 Head and neck squamous cell carcinoma (HNSCC) are associated with recurrence, distant metastasis, and poor overall survival. This highlights the need for identifying potential therapeutics with minimal side-effects.
Ho HY +5 more
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Picrasma quassioides Extract Elevates the Cervical Cancer Cell Apoptosis Through ROS-Mitochondrial Axis Activated p38 MAPK Signaling Pathway. [PDF]
In Vivo, 2020 Background/aim: Picrasma quassioides (P. quassioides) is used in traditional Asian medicine widely for the treatment of anemopyretic cold, eczema, nausea, loss of appetite, diabetes mellitus, hypertension etc.
Gong YX +18 more
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Picrasidine-T, a dimeric β-carboline alkaloid from Picrasma quassioides [PDF]
Phytochemistry, 1987 Abstract A new β-carboline dimeric alkaloid, (±)-picrasidine-T was isolated from the bark of Picrasma quassioides. The structure was determined by spectral analysis and chemical evidence.
Kazuo Koike +2 more
openaire +2 more sources