Results 41 to 50 of about 21,254 (262)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Risk for imbalanced blood pressure pattern among incarcerated women: Middle-Range Theory [PDF]

Revista Brasileira de Enfermagem
Objectives: to develop a Middle-Range Theory for the Risk for imbalanced blood pressure pattern among incarcerated women. Methods: theoretical development study to obtain the theoretical-causal validity of the Nursing Diagnosis Risk for unstable blood ...
Gabrielle Pessôa da Silva, Camila Takáo Lopes, Marcos Venícios de Oliveira Lopes, Ryanne Carolynne Marques Gomes Mendes, Jaqueline Galdino Albuquerque Perrelli, Lívia Maia Pascoal, Suzana de Oliveira Mangueira, Francisca Márcia Pereira Linhares   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Pictorial depth cues elicit the perception of tridimensionality in dogs

Animal Cognition
The perception of tridimensionality is elicited by binocular disparity, motion parallax, and monocular or pictorial cues. The perception of tridimensionality arising from pictorial cues has been investigated in several non-human animal species.
Anna Broseghini, Markus Stasek, Miina Lõoke, Cécile Guérineau, Lieta Marinelli, Paolo Mongillo   +5 more
doaj   +1 more source

Blind suffering: Ribera’s non-visual epistemology of martyrdom [PDF]

The Open Arts Journal, 2015
One of the oft-neglected aspects of early Baroque painting is its critical stance vis-à-vis renaissance’s ideal of pure and perfect visibility. The origins of this standpoint can be traced to the art of Caravaggio, but it is the Hispano-Neapolitan ...
Itay Sapir
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Severity and susceptibility: measuring the perceived effectiveness and believability of tobacco health warnings

BMC Public Health, 2018
Background Pictorial tobacco health warning labels (HWLs) have been shown to be more effective than text-only HWLs in changing smoking attitudes and intentions.
Olivia M. Maynard, Harry Gove, Andrew L. Skinner, Marcus R. Munafò   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Evidence of validity based on the relation to other variable of Pictorial Vocational Interest Inventory

Electronic Journal of Research in Education Psychology, 2023
Introduction.  Analysis of the relationship between test scores and other variables provides an important source of evidence for validity. As a new instrument, evidence of validity of Pictorial Vocational Interest Inventory (PVII) is needed to support its psychometric properties.
Firmanto Adi Nurcahyo, Tience Debora Valentina   +1 more
openaire   +1 more source