Results 111 to 120 of about 308,115 (303)
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Beyond Relativism? Re-engaging Wittgenstein [PDF]
, 2002 Relativism is the view that there are as many worlds as there are ways of thinking and expressing the worlds that are expressed. That is to say, things are related to the ways in which we express them. Thus philosophers assert that the way we express our
Bal, Ramakanta
core
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Advanced Science, EarlyView.We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua +6 more
wiley +1 more source
LEARNING ENGLISH THROUGH AMERICAN FOLKLORE USING INTERACTIVE WEBSITE FOR JUNIOR HIGH SCHOOL STUDENTS [PDF]
, 2013 The development of information technology has affected a lot of aspects in the world. One of the aspects that is influenced by the development is education aspect especially for its learning process.
Wiharto, Dede
core
, 2007 This paper introduces a theory about the role of language in learning physics. The theory is developed in the context of physics students' and physicists' talking and writing about the subject of quantum mechanics.
A. B. Arons +30 more
core +2 more sources
Advanced Science, EarlyView.How can Sn‐based anodes achieve high capacity and long‐life cycling? This work unlocks the potential anode structure by confining Sn in the A layer of MAX phase with Ti6C octahedra as outer immobilization and Fe as inner anchors. The introduction of Fe dramatically strengthens the Ti–Sn bond to enhance structural integrity, modulate interfacial ...
Yu‐ang Lei +13 more
wiley +1 more source
Clause complexes as the basis for construing the narrative point of view in translation context
DELTA: Documentação de Estudos em Lingüística Teórica e AplicadaThis article briefly discusses the role of expansions for construing the characters’ identities and personality traits in Oscar Wilde’s novel The Picture of Dorian Gray and its translation, made by João do Rio, and adaptations, made by Clarice Lispector ...
Adail Sebastião RODRIGUES-JÚNIOR
doaj +1 more source
The Polymers of Life: Exploring Cellular Function Through Polymer Concepts
Advanced Science, EarlyView.Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley +1 more source