Results 71 to 80 of about 1,033,342 (229)

The locus of semantic interference in picture naming [PDF]

Psicológica, 2003
El locus del efecto de interferencia semántica en la denominación de dibujos. En los experimentos que se presentan se utilizó el procedimiento de priming enmascarado para explorar el locus del efecto de interferencia semántica.
Pedro Macizo, M. Carmen Puerta-Melguizo, M. Teresa Bajo   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

fNIRS-Guided neuronavigated rTMS augments naming recovery in subacute post-stroke aphasia: a double-blind randomized controlled trial

Frontiers in Human Neuroscience
BackgroundSelecting an optimal stimulation target is a persistent barrier to maximizing the efficacy of repetitive transcranial magnetic stimulation (rTMS) for subacute post-stroke aphasia.
Haozheng Li, Dongxiang Fang, Dongxiang Fang, Dongxiang Fang, Yihao Chen, Shuqi Xu, Ying Wang, Ying Wang, Wenwen Wei, Ruofan Zhao, Yixian Lai, Yi Wu, Yi Wu, Yi Wu, Qing Yang, Qing Yang, Qing Yang, Ruiping Hu, Ruiping Hu, Ruiping Hu   +19 more
doaj   +1 more source

Getting the picture : iconicity does not affect representation-referent confusion [PDF]

, 2014
Three experiments examined 3- to 5-year-olds' (N = 428) understanding of the relationship between pictorial iconicity (photograph, colored drawing, schematic drawing) and the real world referent.
Emma Corder, Wimmer, MC, Koenig Laura, Wimmer, Marina C., Corder Emma, Laura Koenig, Robinson Elizabeth J., Marina C Wimmer, Corder, Emma, Wimmer Marina C., Koenig, Laura, Robinson, EJ, Robinson, Elizabeth J., Corder, E, Koenig, L, Elizabeth J Robinson   +15 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

EEG Multiscale Complexity in Schizophrenia During Picture Naming

Frontiers in Physiology, 2018
Introduction: Patients with schizophrenia show cognitive deficits that are evident both behaviourally and with EEG recordings. Recent studies have suggested that non-linear analyses of EEG might more adequately reflect the complex, irregular, non ...
Antonio J. Ibáñez-Molina, Vanessa Lozano, María. F. Soriano, José. I. Aznarte, Carlos J. Gómez-Ariza, M. T. Bajo   +5 more
doaj   +1 more source

Lost in semantic space: a multi-modal, non-verbal assessment of feature knowledge in semantic dementia [PDF]

, 2006
A novel, non-verbal test of semantic feature knowledge is introduced, enabling subordinate knowledge of four important concept attributes—colour, sound, environmental context and motion—to be individually probed.
Garrard, P., Carroll, E.
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Is the representation about social groups distinct from that of other concepts? A neuropsychological study

Frontiers in Psychology, 2014
Traditionally neuropsychological observations have constrained the view that semantic knowledge is organized in categories: animals, plants or tools (Warrington & Shallice, 1984; Caramazza & Shelton, 1998; Tyler & Moss, 2001).
Luca Piretti, Andrea Carnaghi, Fabio Campanella   +2 more
doaj   +1 more source