Results 281 to 290 of about 492,550 (353)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

open access: yesBritish Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman   +3 more
wiley   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

open access: yesThe FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal   +8 more
wiley   +1 more source

Optimizing Robust PID Control of Propofol Anesthesia for Children: Design and Clinical Evaluation. [PDF]

open access: yesIEEE Trans Biomed Eng, 2019
van Heusden K   +7 more
europepmc   +1 more source

Non‐native pink salmon Oncorhynchus gorbuscha carcasses benefit native benthic macroinvertebrates

open access: yesJournal of Fish Biology, EarlyView.
Abstract The invasion of the North Atlantic by pink salmon Oncorhynchus gorbuscha has raised concerns regarding their impact on coastal rivers. Although the influence of marine‐derived nutrients from returning adult O. gorbuscha on rivers in their native range has received much attention, the ecological consequences of invasive O.
Hui Wei   +9 more
wiley   +1 more source

Towards an integrated molecular understanding of plant hormones

open access: yesJournal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain   +2 more
wiley   +1 more source

Making the invisible visible: A global examination of careers and recognition for Imaging Scientists in core facilities

open access: yesJournal of Microscopy, EarlyView.
Abstract Imaging facilities underpin a growing share of modern life‐science research, yet the career conditions and scholarly recognition of the Imaging Scientists in core facilities who design, deliver, and interpret imaging research remain uneven. This mismatch has previously been shown to risk loss of expertise, reduced service quality, and weaken ...
Kerry Thompson   +30 more
wiley   +1 more source

What Is Maladaptive in the Emotion Regulation of Personality Pathology? Investigating the Regulation Patterns of Pathological Personality Profiles

open access: yesJournal of Personality, EarlyView.
ABSTRACT Introduction Maladaptive personality traits are viewed as risk factors for personality pathology and are predictive of poor psychological and interpersonal functioning. The study of pathological personality traits has gained increasing popularity, but our knowledge on their association with emotion regulation (ER) processes is limited ...
Sofia Eirini Batziou   +1 more
wiley   +1 more source

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