Results 31 to 40 of about 45,993 (283)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Grazing trajectory statistics and visualization platform based on cloud GIS

Journal of Cloud Computing: Advances, Systems and Applications, 2020
It is very important for ranchers and grassland livestock management departments to master the information on the trajectory and feeding behavior of the herd timely and accurately.
Dong Li, Chuanjian Wang, Qilei Wang, Tianying Yan, Wanlong Bing, Ju Wang   +5 more
doaj   +1 more source

Chronic Constrictive Pericarditis in a low-income-setting: Challenges and Outcome of Surgery

Ibom Medical Journal, 2022
Background: In a low-income setting like ours, chronic constrictive pericarditis is not uncommon. Affected patients present late for surgical management owing to poverty and ignorance. These two factors adversely affect the outcome of surgery. Objective:
Nwafor IA, Nwafor MN, Eze AC
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Differential effect of pre and post cognitive skills training program: a study on healthy young children

Smart Learning Environments, 2022
The objective of this research paper is to check the difference between pre and post-session of the Brighter Minds based Cognitive Skill Training. The exploratory and descriptive research design is used in this study.
Ramesh Kumar Chaturvedi, Vishal Verma, Kushendra Mishra   +2 more
doaj   +1 more source

Knowledge, attitude, and awareness of biocompatibility of orthodontic materials among dental students

Journal of Advanced Pharmaceutical Technology & Research, 2022
The aim of this study is to find the knowledge, attitude and awareness of biocompatibility of orthodontic materials among dental students.A survey of 13 questions was created using Google Forms.
Shabbarish Chockalingam, Nivethigaa Balakrishnan   +1 more
doaj   +1 more source

Novel Functional Materials via 3D Printing by Vat Photopolymerization

Advanced Functional Materials, EarlyView.
This Perspective systematically analyzes strategies for incorporating functionalities into 3D‐printed materials via Vat Photopolymerization (VP). It explores the spectrum of achievable functionalities in recently reported novel materials—such as conductive, energy‐storing, biodegradable, stimuli‐responsive, self‐healing, shape‐memory, biomaterials, and
Sergey S. Nechausov, Patrick Fesser, Boris A. Bulgakov, Ulrich S. Schubert   +3 more
wiley   +1 more source

RISK MANAGEMENT ON RAILWAY PROJECTS: A LITERATURE VIEW

Facta Universitatis. Series: Architecture and Civil Engineering, 2020
Railway construction either underground or in an open area or under a bridge carries work risks. The same in the process of design, implementation or maintenance.
Toni Yuri Prastowo, Humiras Hardi Purba
doaj   +1 more source