Results 71 to 80 of about 260,355 (166)

Techno‐economic analysis of membrane‐based continuous capture chromatography platforms for large‐scale antibody production

Biotechnology Progress, EarlyView.
Abstract Continuous manufacturing platforms and membrane chromatography are process technologies with the potential to reduce production costs and minimize process variability in monoclonal antibody production. This study presents a simulation and optimization framework to perform techno‐economic analyses of these strategies.
Juan J. Romero, Eleanor W. Jenkins, Marc R. Birtwistle, Scott M. Husson   +3 more
wiley   +1 more source

A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS‐CoV‐2 spike protein production as a vaccine antigen

Biotechnology Progress, EarlyView.
Abstract Fed‐batch recombinant therapeutic protein (RTP) production processes utilizing Chinese Hamster Ovary (CHO) cells can take a long period of time (>10 days). Within this period, not all critical features may be measured routinely, and in fact, some are only measured once the process is terminated, complicating decision making.
Sebastian‐Juan Reyes, Robert Voyer, Yves Durocher, Olivier Henry, Phuong Lan Pham   +4 more
wiley   +1 more source

Piecewise linear source separation [PDF]

SPIE Proceedings, 2003
We propose a new framework, called piecewise linear separation, for blind source separation of possibly degenerate mixtures, including the extreme case of a single mixture of several sources. Its basic principle is to : 1/ decompose the observations into ``components'' using some sparse decomposition/nonlinear approximation technique; 2/ perform ...
openaire   +4 more sources

Automated analysis of flow cytometry data with minimal training files: Research evaluation of an elastic image registration algorithm for TBNK, stem cell enumeration, and lymphoid screening tube assays

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Automated analysis of flow cytometry data can improve objectivity and reduce analysis time but has generally required work by software and algorithm experts. Here, we investigated the performance of BD ElastiGate™ Software (hereafter ElastiGate), which allows users to automate gating by selecting gated training files, then uses elastic image ...
Allison Irvine, Suhail Tahir, Vishnu Tripathi, Farzad Oreizy, Moen Sen, Anthony Giuliano, Anna Lin, Angela Chen, Chih‐Hung Lai, Imelda Omana‐Zapata, Yang Zeng, Paresh Jain, Scott J. Bornheimer   +12 more
wiley   +1 more source

Experimental and constitutive modeling investigations on marble in Jinping Underground Laboratory

Deep Underground Science and Engineering, EarlyView.
The objective of this study is to reveal the underlying mechanisms behind the brittle‐ductile transition of the marble through a combination of experimental research and constitutive modeling. A series of triaxial compression and triaxial cyclic loading tests are conducted.
Susheng Wang, Qiang Zhang, Hao Luo, Zhinan Lin   +3 more
wiley   +1 more source

A novel construction approach for the pore structure model principally focuses on the controllable roundness of rock particles

Deep Underground Science and Engineering, EarlyView.
Particle rounding effects comparison of different methods: (a), (b), and (c) are the rounding results using the B‐spline curve method with different R; (d), (e), and (f) are the results of vertex rounding substitution method with different rounding radii.
Jiabin Dong, Ning Yang, Yi Jin, Ying Wu, Dandan Liu, Junling Zheng, Jingyan Zhao   +6 more
wiley   +1 more source

Electrokinetic Power‐Series Solution in Narrow Cylindrical Capillaries for All Zeta Potentials

ELECTROPHORESIS, EarlyView.
ABSTRACT Work from Rice and Whitehead showed the results of electrokinetic flow in a capillary tube under the assumption of low zeta potential <$<$25 mV, limiting the approximation's usability. Further research conducted by Philip and Wooding provided an alternative solution that assumes high zeta potentials >$>$25 mV and relies on Rice and Whitehead's
Sam Khalifa, Arturo Villegas, Francisco J. Diez   +2 more
wiley   +1 more source

O-minimal Hauptvermutung for polyhedra II

, 2016
Hilbert initiated the standpoint in foundations of mathematics. From this standpoint, we allow only a finite number of repetitions of elementary operations when we construct objects and morphisms. When we start from a subset of a Euclidean space. Then we
Shiota, Masahiro
core  

Comparing Different Light Models for Virtual Electrodes in Optoelectronic Tweezers

ELECTROPHORESIS, EarlyView.
ABSTRACT Optoelectronic tweezers (OET) allow for the physical manipulation of particles of interest via dielectrophoresis (DEP) in microfluidic devices. To produce the nonuniform electric field required to enable DEP, light is used to expose a photoconductive film and create a so‐called virtual electrode (VE).
Ernesto Guzman‐Saleh, Victor H. Perez‐Gonzalez, Rodrigo Martinez‐Duarte   +2 more
wiley   +1 more source

Dynamics of piecewise isometries

Illinois Journal of Mathematics, 2000
We begin a systematic study of Euclidean piecewise isometric dynamical systems (p.i.d.s.) with a particular focus on the interplay between geometry, symbolic dynamics, and the group of isometries associated with p.i.d.s. We investigate various aspects of the dynamical information contained in the coding: symbolic growth and the periodic behavior of ...
openaire   +3 more sources