Results 21 to 30 of about 9,717 (219)

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

A practical analysis of ecological continuity on diverse territorial scales - Example of a method employed prior to the French ecological-network project [PDF]

Sciences, Eaux & Territoires, 2011
The Environmental agency in the Franche Comté region discusses here the method tested during early programmes for ecological continuity.
PIEL, Arnaud, PIEL, Arnaud
doaj  

Síndrome de netherton: reporte de un caso

Ciencia y Salud
El síndrome de Netherton (SN) es una enfermedad con herencia autosómica recesiva caracterizada por la triada clínica: ictiosis lineal circunfleja, diátesis atópica y anormalidades del tallo piloso.
Daisy M. Blanco, Jhonnisa Suarez, Arianna Estévez, Alexa Estévez   +3 more
doaj   +1 more source

Pour une analyse pratique des continuités écologiques à diverses échelles de territoire – Exemple de quelques éléments méthodologiques initiés avant la Trame verte et bleue [PDF]

Sciences, Eaux & Territoires, 2010
La Direction régionale de l'Environnement, de l'Aménagement et du Logement de Franche Comté nous livre ici quelques réflexions sur des éléments méthodologiques qui ont été éprouvés lors des premiers programmes de mise en œuvre des continuités écologiques.
PIEL, Arnaud, PIEL, Arnaud
doaj  

Microsporum spp. onychomycosis: disease presentation, risk factors and treatment responses in an urban population

Brazilian Journal of Infectious Diseases, 2014
Background: Dermatophytes are the main causative agent of all onychomycosis, but genus Microsporum is infrequent and the risk of acquiring the infection is often associated with exposure to risk factors.
Erick Martínez, Mahreen Ameen, Diana Tejada, Roberto Arenas   +3 more
doaj   +1 more source

Rainwater, a tool for development and maintenance of nature in the city - Three development projects illustrating the water as a support of natural processes in urban environment

Проект Байкал, 2013
The problems of manage urban stormwater are gradually taken into account by planners and landscapers. If the ecological potential of the temporary retention techniques is correctly operated in peri-urban areas, it is too little valued in a dense urban ...
Christian Piel
doaj   +1 more source

High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello, Rui Xiao, Xuemei Zhang, Jahan Jazayeri, Irit R. Rasooly, Pamela F. Weiss   +5 more
wiley   +1 more source

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources