Results 31 to 40 of about 207 (193)

Poisson's Ratio‐Driven Control of Myogenic Differentiation and Maturation in Auxetic Metamaterials under Dynamic Mechanical Stimulation

Advanced Functional Materials, EarlyView.
This study explored how innovative “auxetic” scaffolds, which expand when stretched, influence skeletal muscle development. Researchers cultured muscle cells on different scaffold designs and applied repeated stretching over 10 days. They found that scaffold geometry affected muscle cell differentiation and fiber formation.
Maria Kalogeropoulou, Prabhdeep Kaur, Monica Boffito, Pierpaolo Fucile, Gianluca Ciardelli, Lorenzo Moroni   +5 more
wiley   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Establishment of a Responsive Tooth‐on‐a‐Chip Platform for the Assessment of Regenerative Factors in Dental Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Using a tooth‐on‐a‐chip model that recreates interactions between dental epithelial and mesenchymal cells, the authors show that sequential FGF10+BMP4, BMP2, and Emdogain produce distinct, biologically consistent regenerative responses. The platform recapitulates known signal‐specific effects and, for the first time, reveals an influence of Emdogain on
Chong Huang, Wei Ji, Fang Yang, X. Frank Walboomers   +3 more
wiley   +1 more source

An Engineered Thio‐Amino Polymer Achieves Potent, Safe, and Broad Cell Type Delivery in the Lung Mapped by Spatial Transcriptomics

Advanced Materials, EarlyView.
Synthesis and screening of a polymer library produced a versatile and inhalable mRNA vehicle for the lungs (P81). Compared to a published LNP, P81 provides increased delivery efficacy, achieving widespread expression in broad cell types, with no toxicity.
Pramodkumar EK, Younghun Jung, Elex S. Rose, Jae Yeon Joo, James R. Rose, José A. F. Assumpção, Hyeyoon Jeong, Lorena C. S. Chaves, Blake Andrew Miller, João Paulo Pera Mendes, Hannah E. Peck, Charmy J. Patel, Loren E. Sasser, Heather Pathak, Varun V. Mosur, Jaehyeon Hwang, Guilherme de Oliveira Lopes, Merrilee Thoresen, Santiago Cornejo, Peres Badial, Alicia Olivier, Amelia R. Woolums, Samuele Stazzoni, Noemi Manganaro, Eleonora Nencini, Giulio Pierleoni, Emanuele Andreano, Rino Rappuoli, Nichole Orr‐Burks, Sarah R. Hosking, Nicholas S. Heaton, Eric R. Lafontaine, Robert J. Hogan, Francois Villinger, Daryll Vanover, Chiara Zurla, Philip J. Santangelo   +36 more
wiley   +1 more source

Comparative In Vitro Studies of Materials Properties of Uncoated and Multifunctional/Biocompatible Ultrananocrystalline Diamond (UNCD) Coated‐Bioactive Bovine Nanohydroxyapatite Scaffolds for Transformational Bone Tissue Engineering

Advanced Materials Interfaces, EarlyView.
Research/technology development demonstrated physicochemical/mechanical properties of transformational integration of hydroxyapatite (HAp) scaffolds and HAp scaffolds coated with a unique breakthrough biocompatible ultrananocrystalline diamond (UNCD) coating produced by microwave plasma chemical vapor deposition (MPCVD) process.
Angelica M. Castillo‐Paz, Leon R. Bernal‐Alvarez, Dorian F. Cañon‐Davila, Lerma H. Chan‐Chan, Orlando Auciello, Rafael Ramírez‐Bon, Mario E. Rodriguez‐Garcia   +6 more
wiley   +1 more source

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

Customizable Piezo‐Transmittance‐Based Multiaxial Force Sensor With Deep‐Learning‐Assisted Sensing

Advanced Materials Technologies, EarlyView.
Development of a soft tri‐axis piezo‐transmittance sensor with integrated LEDs and photodiodes enables multidirectional force sensing through deformation‐induced optical modulation. A tailored 1D convolutional neural network provides real‐time force direction and intensity prediction, achieving 99.6% classification accuracy and a mean squared error of ...
Filippo Peruzzi, Osman Gul, Wonhee Lee, Seokjoo Cho, Yong‐Jin Yoon, Paola Saccomandi, Inkyu Park   +6 more
wiley   +1 more source

Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation

Advanced Materials Technologies, EarlyView.
Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching, Hinako Ichikawa, Aya Motoyoshi, Shin Tanaka, Liam Morrow, Satoshi Shirae, Noriko Sakai, Shohei Kitahata, Michiko Mandai, Kazuaki Kadonosono   +9 more
wiley   +1 more source

Microneedles Fabrication by Substrate‐Independent Electrostretching and In‐Situ Focused Electrospray Deposition for Transdermal Drug Delivery

Advanced Materials Technologies, EarlyView.
A novel electrohydrodynamic platform integrating substrate‐independent in situ dried electrostretching (SI‐PIDES) and in situ focused electrospray deposition (IFED) enables mold‐free fabrication and precise drug coating of flexible core–sheath microneedle patches.
Ngoc Luan Mai, Dinh Nghi Ngo, Yuqing Mu, Thien Xuan Dinh, Yin Xiao, Dzung Viet Dao, Yuen Kuan Yong, Van Thanh Dau   +7 more
wiley   +1 more source

Waveguide Photoactuators: Materials, Fabrication, and Applications

Advanced Robotics Research, EarlyView.
Waveguide photoactuators convert guided light into mechanical motion. Their tethered‐flexible design enables minimally invasive surgery and confined‐space robotics. This review aims to guide materials selection, device design, and system integration, accelerating the transition of waveguide photoactuators from laboratory prototypes to versatile ...
Minjie Xi, Hemin Pan, Yang Zong, Yongfeng Mei, Jizhai Cui   +4 more
wiley   +1 more source