Measurement and evaluation of surgical models of spinal fusion in mice, rats, and rabbits
Animal Models and Experimental Medicine, EarlyView.In this study, spinal fusion models in mice, rats and rabbits are compared and discussed. The results show that after comparing the anatomical structure and the complexity of surgical operation, among the three experimental animals in this study, the rabbit as an experimental animal is superior to the mouse and the rat in the establishment of spinal ...
Jianghong Lu, Yicun Hu, Xin Yao
wiley +1 more source
Maternal docosahexaenoic acid supplementation shapes offspring gut microbiota to modulate the gut-brain axis in a sow-piglet model. [PDF]
Front NutrLee S +6 more
europepmc +1 more source
Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection
Animal Models and Experimental Medicine, EarlyView.A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang +9 more
wiley +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Empowering large litters: can enhanced pen design with simulated udders improve piglet growth in their early life? [PDF]
Transl Anim SciMadsen JG +4 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source
Multi-omics analysis reveals maternal gut microbiota-derived short-chain fatty acids and progesterone are associated with offspring birth weight in sows. [PDF]
Front MicrobiolXu X, Chen Y, Ye Q, Xu B, Yan X.
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang +12 more
wiley +1 more source
Radar-Based Monitoring: A Proof of Principle Study in a Piglet Model for a Novel Approach in Non-Contact Vital Sign Monitoring. [PDF]
Sensors (Basel)Goedicke-Fritz S +12 more
europepmc +1 more source