Results 21 to 30 of about 134,357 (248)

C-type lectin receptors in skin immunity: Emerging new role for CLEC12B

Advances in Biomedical and Health Sciences, 2022
C-type lectin receptors (CLRs) are a superfamily of transmembrane proteins, which consist of one or several C-type lectin-like domains and intracellular signaling motifs, such as immunoreceptor tyrosine-based activation motif (ITAM) or immunoreceptor ...
Lauriane Blot, Thierry Passeron, Meri K Tulic   +2 more
doaj   +1 more source

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

eLife, 2016
The association between pregnancy and altered cutaneous pigmentation has been documented for over two millennia, suggesting that sex hormones play a role in regulating epidermal melanocyte (MC) homeostasis.
Christopher A Natale, Elizabeth K Duperret, Junqian Zhang, Rochelle Sadeghi, Ankit Dahal, Kevin Tyler O'Brien, Rosa Cookson, Jeffrey D Winkler, Todd W Ridky   +8 more
doaj   +1 more source

Fossil pigments [PDF]

Current Biology, 2016
Johan Lindgren introduces fossil pigments.
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Genetics and Expression Analysis of Anthocyanin Accumulation in Curd Portion of Sicilian Purple to Facilitate Biofortification of Indian Cauliflower

Frontiers in Plant Science, 2020
The present study was undertaken to know the genetics of purple color of cauliflower curds using a Sicilian purple ‘PC-1’ and a white curding mid-late group genotype of Indian cauliflower. For this, a cross was attempted between ‘DC-466’ (white curd) and
Shrawan Singh, Pritam Kalia, Rahul Kumar Meena, Manisha Mangal, Sabina Islam, Supradip Saha, Bhoopal S. Tomar   +6 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Comprehensive metabolome and transcriptome analyses demonstrate divergent anthocyanin and carotenoid accumulation in fruits of wild and cultivated loquats

Frontiers in Plant Science, 2023
Eriobotrya is an evergreen fruit tree native to South-West China and adjacent countries. There are more than 26 loquat species known in this genus, while E.
Wenbing Su, Changqing Zhu, Zhongqi Fan, Mingkun Huang, Han Lin, Xiuping Chen, Chaojun Deng, Yongping Chen, Yidan Kou, Zhihong Tong, Zhihong Tong, Yaling Zhang, Changjie Xu, Shaoquan Zheng, Jimou Jiang   +14 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source