Results 211 to 220 of about 5,960,249 (275)

Clinical and genetic features of pediatric hereditary polyposis syndromes in Israel: A nationwide multicenter cohort

open access: yesJournal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 4, Page 637-643, October 2026.
Abstract Objectives Hereditary polyposis syndromes in children are rare, heterogeneous disorders associated with significant morbidity and long‐term risk of malignancy. Current data on their presentation, management, and outcomes in pediatric populations remain limited.
Shlomi Cohen   +9 more
wiley   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang   +8 more
wiley   +1 more source

An explainable deep learning model classifies eight categories of pigmented skin lesions on clinical photographs: A multicenter retrospective internal validation study in Japan. [PDF]

open access: yesJAAD Int
Iinuma K   +12 more
europepmc   +1 more source

Organoids: Current Applications and Future Directions

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng   +14 more
wiley   +1 more source

Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu   +6 more
wiley   +1 more source

Advanced Glycation End Products: From Pathogenesis to Treatment

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Therapeutic landscape of AGE‐targeted intervention. Schematic representation of intervention strategies targeting distinct stages of AGE biology. Upstream prevention aims to reduce exposure and formation through low‐AGE cooking, smoking cessation, glycemic control, and metabolic optimization.
Tak‐Ho Lo   +7 more
wiley   +1 more source

Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity

open access: yesThe Journal of Pathology, Volume 270, Issue 2, Page 226-240, October 2026.
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch   +7 more
wiley   +1 more source

Impacts of Nuclear War on Human Health From Changed Surface Ultraviolet Radiation

open access: yesEarth's Future, Volume 14, Issue 10, October 2026.
Abstract Climate model simulations indicate that surface ultraviolet (UV) radiation would change after soot injection into the stratosphere during a nuclear war, due to the competing effects of ozone depletion and aerosol attenuation. Using climate model simulations, we evaluate UV impacts under two scenarios: a regional India‐Pakistan conflict ...
Shu Xu   +6 more
wiley   +1 more source

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