Results 141 to 150 of about 739,845 (308)

Transmission of African swine fever virus from infected pigs by direct contact and aerosol routes.

Veterinary Microbiology, 2017
A. Olesen, L. Lohse, A. Boklund, T. Halasa, C. Gallardo, Z. Pejsak, G. Belsham, T. Rasmussen, A. Bøtner   +8 more
semanticscholar   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Pharmacological and light-driven pupillary accommodation in guinea pigs: comparative effects of muscarinic modulators and illumination across developmental stages. [PDF]

Int J Ophthalmol
Wu H, Lu N, Qiao ZB, Cheng C, Luo WT, Wan T, Qiao T, Di Y.   +7 more
europepmc   +1 more source

Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning

Science, 2002
L. Lai, D. Kolber-Simonds, Kwang‐Wook Park, H. Cheong, J. Greenstein, G. Im, M. Samuel, A. Bonk, A. Rieke, B. N. Day, C. Murphy, D. B. Carter, R. Hawley, R. Prather   +13 more
semanticscholar   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Integrating sequence-based GWAS and comparative genomic analysis reveals conservation and species-specificity of putative functional variants influencing tail length and tail abnormalities in pigs and sheep. [PDF]

PLoS One
Zhang X, Mainzer J, Giambra I, Yin T, Engel P, Hümmelchen H, Wagner H, Wehrend A, Egerer C, Gerhards K, Reiner G, König S.   +11 more
europepmc   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses. [PDF]

PLoS Pathog
Yang X, Zhong H, Cheng J, Jiang H, Tan J, Wang C, Song C, Cai G, Yang H, Wu Z.   +9 more
europepmc   +1 more source

Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots

Advanced Science, EarlyView.
Crustacean exoskeletons, repurposed from food waste, are engineered into sustainable bending actuators combining biotic structure with synthetic control. The augmented exoskeletons achieve rapid and robust motion with lightweight body and can be used as part of robotic manipulators, grippers and swimmers.
Sareum Kim, Kieran Gilday, Josie Hughes
wiley   +1 more source

Computed Tomographic Grading of Ear Diseases in Guinea Pigs (Cavia porcellus). [PDF]

Vet Radiol Ultrasound
Brennan T, Beauvois M, Pignon C, Coutant T, Muffat-Es-Jacques P, Penel E, Gomes E, Huynh M, Hahn H.   +8 more
europepmc   +1 more source