Results 171 to 180 of about 31,115 (236)

Microneedle ocular patch: fabrication, characterization, and ex-vivo evaluation using pilocarpine as model drug

Drug Development and Industrial Pharmacy, 2020
Context: Enhacing the ocular bioavailability of drugs after their topical application is a challenge. Objective: The objective of the study was to design, fabricate, and investigate the effectiveness of microneedle ocular patch (MOP) in delivering the ...
G. Roy, Rohini Devi Galigama, Veda Suresh Thorat, P. Garg, V. K. Venuganti   +4 more
semanticscholar   +1 more source

Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission.

Journal of Ethnopharmacology, 2020
ETHNOPHARMACOLOGICAL RELEVANCE Temporal lobe epilepsy remains one of the most drug-resistant focal epilepsy, leading to enormous healthcare burden. Among traditional herb medicine, some ingredients have the potential to treat seizure and alleviate the ...
Chih-Sheng Yang, S. Chiu, Ping-Yen Liu, Sheng-Nan Wu, Ming‐Chi Lai, Chin-Wei Huang   +5 more
semanticscholar   +1 more source

Topical pilocarpine for xerostomia in patients with head and neck cancer treated with radiotherapy.

Oral Diseases, 2020
OBJECTIVE To evaluate a pilocarpine spray as a treatment for xerostomia in patients treated with radiotherapy (RT) for head and neck cancer (HNC). METHODS This was a placebo-controlled, double-blind, crossover clinical trial of patients complaining of ...
Raony Môlim de Sousa Pereira, M. D. R. Bastos, M. P. Ferreira, O. de Freitas, Leandro Dorigan de Macedo, H. Oliveira, H. Ricz, A. C. Motta, A. P. Macedo, C. Tirapelli, V. Pedrazzi   +10 more
semanticscholar   +1 more source

Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy.

Behavioural Brain Research, 2019
The aim of this study was to evaluate in detail behavioral patterns and comorbid disturbances in rats using the lithium-pilocarpine model. A comprehensive set of behavioral tests was used to investigate behavioral patterns, including the open field test,
I. Smolensky, O. Zubareva, S. Kalemenev, V. V. Lavrentyeva, A. V. Dyomina, A. A. Karepanov, A. Zaitsev   +6 more
semanticscholar   +1 more source

Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy.

Neuroscience, 2019
Neuroinflammation plays an important role in epileptic disorders. Toll-like receptors (TLRs) are the key signal transduction tools by which neuroinflammation may promote epileptogenesis.
M. Hosseinzadeh, H. G. Pourbadie, F. Khodagholi, Mahtab Daftari, N. Naderi, F. Motamedi   +5 more
semanticscholar   +1 more source

Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium‐pilocarpine‐induced status epilepticus

The Journal of pharmacy and pharmacology, 2018
It has been proven that extracellular HMGB1 is involved in progression of neurologic disorders, such as stroke, traumatic brain injury, meningitis and epilepsy.
Ya-Jun Li, Lin Wang, Bei Zhang, Fei Gao, Chun-mei Yang   +4 more
semanticscholar   +1 more source

Benefits of long-term pilocarpine due to increased muscarinic acetylcholine receptor 3 in salivary glands.

Biochemical and Biophysical Research Communications - BBRC, 2018
Hypofunction of the salivary gland causes several life-disrupting side effects such as dental caries, oral candidiasis, loss of taste, and swallowing disorders. No satisfactory therapy has been established to treat salivary hypofunction.
H. Minagi, Kazuki Ikai, Takafumi Araie, Manabu Sakai, Takayoshi Sakai   +4 more
semanticscholar   +1 more source

Pilocarpine

2007
Pilocarpine is a direct-acting parasympathomimetic agent exerting a broad spectrum of pharmacological actions mediated through muscarinic acetylcholine receptors. It is non-selective for the various muscarinic receptors and does not stimulate nicotinic acetylcholine receptors.
openaire   +2 more sources

Serum Pilocarpine Esterase Activity and Response to Oral Pilocarpine

Biochemical and Molecular Medicine, 1996
Pilocarpine is used orally to treat xerostomia but patients vary widely in their response and ability to tolerate this drug. To elucidate the potential pharmacokinetic contribution of serum to this variability, the enzymatic hydrolysis of pilocarpine in human serum in vitro was investigated using a stability indicating HPLC assay.
C, Aromdee, J P, Fawcett, M M, Ferguson, R, Ledger   +3 more
openaire   +2 more sources

Pilocarpine

Reactions Weekly, 2022
openaire   +2 more sources