Results 61 to 70 of about 14,660,005 (345)

How do pilot and feasibility studies inform randomised placebo-controlled trials in surgery? A systematic review

BMJ Open, 2023
Introduction Randomised controlled trials (RCTs) with a placebo comparator are considered the gold standard study design when evaluating healthcare interventions. These are challenging to design and deliver in surgery.
Jane M Blazeby, David J Beard, Natalie S Blencowe, Sian Cousins, Katy Chalmers, Marion K Campbell, Alexander Gormley   +6 more
doaj   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Pilot design for underwater MIMO cosparse channel estimation based on compressed sensing

International Journal of Distributed Sensor Networks, 2021
In multiple-input multiple-output–orthogonal frequency-division multiplexing underwater acoustic communication systems, the correlation of the sampling matrix is the key of the channel estimation algorithm based on compressed sensing. To reduce the cross-
Yun Li, Lingxia Liao, Shanlin Sun, Zhicheng Tan, Xing Yao   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Mitigation pilot contamination based on matching technique for uplink cell-free massive MIMO systems

Scientific Reports, 2022
In this paper, the cell-free massive multiple input multiple output (MIMO) network is affected by the pilot contamination phenomenon when a large number of users and a small number of available pilots exists, the quality of service (QoS) will deteriorate
Abdulrahman Al Ayidh, Yusuf Sambo, Muhammad Ali Imran   +2 more
doaj   +1 more source

The Value of Design-led Innovation in Chinese SMEs [PDF]

, 2009
Organised by: Cranfield UniversityThis paper focuses on understanding the role and use of design-led innovation in Chinese SMEs. The insights were gained by undertaking a pilot study, based on an applied developmental research approach involving ...
Bolton, S.
core  

A pilot design for observational studies: Using abundant data thoughtfully

Statistics in Medicine, 2019
Observational studies often benefit from an abundance of observational units. This can lead to studies that—while challenged by issues of internal validity—have inferences derived from sample sizes substantially larger than randomized controlled trials ...
Rachael C. Aikens, Dylan Greaves, M. Baiocchi   +2 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Safe environments for innovation: developing a new multidisciplinary masters programme [PDF]

, 2010
This paper outlines the research and resulting curriculum design activities conducted as a collaborative venture between Northumbria University’s School of Design, School of Computing, Engineering and Information Sciences and Newcastle Business School ...
Bailey, Mark, Smith, Neil
core