Results 41 to 50 of about 9,337,847 (203)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Totara Industry Pilot project: Final summary report

open access: yes, 2020
Totara Industry Pilot project: Final summary report, V2.1 August ...
Elizabeth Dunningham, Greg Steward, Paul Quinlan, Dejan Firm, Doug Gaunt, Steve Riley, John Lee, Andrew Dunningham, Ramona Radford
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Pilot Rock Notice of Adopted Amendment (2007-05-07)

open access: yes, 2007
9 pp. Adopted 2007-05-07. Department of Land Conservation and Development Notice of Adopted AmendmentWe annexed 445 acres into the City of Pilot Rock.
Pilot Rock (Or.)
core   +1 more source

New Approaches to the Training of Educational Psychologists

open access: yesВестник Московского Университета. Серия 20: Педагогическое образование
Background. In modern conditions of building a sovereign national system of education, the development of domestic higher education, the task of implementing a pilot project, with participation of MPGU.
Tatiana N. Sakharova   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Die Toolbox: Das neue Informationskompetenzangebot der Ärztlichen Zentralbibliothek des Universitätsklinikums Hamburg-Eppendorf

open access: yesGMS Medizin – Bibliothek – Information, 2017
In 2017, the Central Medical Library started a new course on information literacy to actively support the students in their studies. In this course, e-contents supplement face-to-face lessons.
Rümmele, Sandra
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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