Results 51 to 60 of about 994,485 (286)

Exploration on the Training and Evaluation Mode of Clinical Postdoctoral Trainees in Radiology Department Based on Core Competence

Xiehe Yixue Zazhi, 2022
The postdoctoral training program of clinical medicine explores a new form of medical elite education in China. As one of the first pilot departments of the clinical postdoctoral program of Peking Union Medical College Hospital, Radiology Department has ...
CHEN Yu, XUE Huadan, ZHANG Daming, SHI Yuxi, SUN Hao, DING Ning, SU Tong, ZHU Huijuan, JIN Zhengyu, ZHANG Shuyang   +9 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Co-production of an online research and resource platform for improving the health of young people-The hype project.

PLoS ONE
Mental health conditions tend to go unrecognised and untreated in adolescence, and therefore it is crucial to improve the health and social outcomes for these individuals through age and culturally appropriate interventions.
Cerisse Gunasinghe, Nicol Bergou, Shirlee MacCrimmon, Rebecca Rhead, Charlotte Woodhead, Jessica D Jones Nielsen, Stephani L Hatch   +6 more
doaj   +1 more source

EXCELLENT SCHOOL, STATUS AND ITS EXISTENCE

Englisia, 2014
The excellent school and effective school share their characteristics. Their main characteristic is that higher student academic achievement and there is no disparity or gap across the scores gained.
Syarwan Ahmad
doaj   +1 more source

Geo-questionnaire in urban planning – preliminary results of the experimental application in Poland [PDF]

, 2016
Changes in the attitude of local authorities towards the public participation in the decision making processes have prompted development of new methods of such involvement.
Brudka, Cezary, Bąkowska, Edyta, Czepkiewicz, Michał, Jankowski, Piotr, Kaczmarek, Tomasz, Mikuła, Łukasz, Zwoliński, Zbigniew   +6 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Technical paper on Twin screw extruder processing technology for fibres as raw material for peat substitution [PDF]

, 2019
One important aim of the Organic-PLUS project is to develop resource and energy efficient technologies to produce fibres from lignocellulosic plant materials as a raw material to substitute peat. For this purpose, Leibniz Institute für Agrartechnik und
Dittrich, Christian, Løes, Anne-Kristin, Pecenka, Ralf, Schmutz, Ulrich   +3 more
core  

The learning network on sustainability: An e-mechanism for the development and diffusion of teaching materials and tools on design for sustainability in an open-source and copy left ethos [PDF]

, 2011
This is the post-print version of the Article. The official published version can be obtained from the link below - Copyright @ 2011 InderscienceThis paper presents the intermediate results of the Learning Network on Sustainability (LeNS) project, Asian ...
Ceschin, F, Vezzoli, C
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source