Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
How to promote innovation and interdisciplinarity in organic food and farming research evaluation [PDF]
The development of organic food and farming research calls for system-oriented, innovative, interdisciplinary approaches. The process of evaluating research proposals is a crucial step towards this objective.
Alföldi, Thomas +3 more
core
Critical success factors influencing performance outcome of joint venture construction projects in South Africa: Comparison of first and second order models [PDF]
Joint ventures (JVs) have become increasingly common, because of the complexity and challenges associated with the delivery of construction projects globally and in South Africa.
Agumba, Justus Ngala +1 more
core +3 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Cost-benefit analysis of Smart Grid projects: Isernia: Costs and benefits of Smart Grid pilot installations and scalability options [PDF]
Smart Grid pilot projects and their assessment through a cost-benefit analysis are crucial to ensure that Smart Grid and Smart Metering roll-out are economically reasonable and cost-effective.
FLEGO GIANLUCA +4 more
core +2 more sources
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
National evaluation of Partnerships for Older People Projects [PDF]
Executive Summary The Partnership for Older People Projects (POPP) were funded by the Department of Health to develop services for older people, aimed at promoting their health, well-being and independence and preventing or delaying their need for ...
D'Amico, Francesco +5 more
core
Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein +13 more
wiley +1 more source
Developing Offset Banking Systems in Georgia [PDF]
Offset banking involves a public or private entity investing in a project that has the effect of substantially reducing a targeted pollutant(s), such as sediment runoff, phosphorus, heavy metals, etc. This project is referred to as "the bank." The entity
Laura O. Taylor +2 more
core
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source

