Results 251 to 260 of about 4,400,866 (286)

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Development and application of a standardized teaching assessment system for digital automated oral implantation planning skills: a randomized controlled pilot trial. [PDF]

Front Oral Health
Li S, Hou K, Zhang Y, Wang W, Liu Z, Zhang H, Ma Z.   +6 more
europepmc   +1 more source

A Digital Registry and Education Network for Child Maltreatment Protection: Protocol for a Pilot Observational Exploratory Intervention Study. [PDF]

JMIR Res Protoc
Zuccotti G, Dilillo D, Agosto A, Brazzoduro V, Marinelli EBL, Calcaterra V.   +5 more
europepmc   +1 more source

Rotor-Wing Pilot AMS Mission Specific Training

USDOE National Nuclear Security Administration (NNSA), Piotr T. Wasiolek, NNSS/MSTS (NNSS-MSTS)   +2 more
openalex   +2 more sources

Spatial disorientation and countermeasure training for next-generation aircraft: a review and recommendations. [PDF]

Front Physiol
Kim JJ, Kirollos R.
europepmc   +1 more source

EFFECT OF PERTURBATION BASED TRAINING AND TREADMILL TRAINING ON GAIT AND BALANCE AMONG ATTENTION DEFICIT HYPERACTIVITY DISORDER: A PILOT STUDY

Saravanan V, Mohan Kumar G, M Manikumar, Ramachandran S   +3 more
openalex   +2 more sources

Feasibility of Self-Directed Learning of Cardiopulmonary Resuscitation Skills Using Interactive Video in SimZone 0: Pilot Randomized Educational Trial. [PDF]

JMIR Form Res
Trampal Ramos Á, Charneco Salguero G, González-Tejerina B, Moreno-Palacios E, Leal-Costa C.   +4 more
europepmc   +1 more source

High-Impact Structured Airway Training With Simple Task Trainers (Pilot): A One-Hour Integrated Simulation for Novice Medical Students

Daniel Tapia, Yasser Abdul Bagi, Anurag Sandhu, Cristian Salazar   +3 more
openalex   +1 more source