Inclusion of progression criteria in external randomised pilot trials: a cross-sectional study of funding applications submitted to the NIHR Research for Patient Benefit Programme [PDF]
Trials, 2022 Background External randomised pilot trials aim to assess whether a future definitive randomised controlled trial (RCT) is feasible. Pre-specified progression criteria help guide the interpretation of pilot trial findings to decide whether, and how, a ...
Katie Mellor +5 more
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More pilot trials could plan to use qualitative data: a meta-epidemiological study [PDF]
Pilot and Feasibility Studies, 2020 Background Pilot trials often use quantitative data such as recruitment rate and retention rate to inform the design and feasibility of a larger trial. However, qualitative data such as patient, healthcare provider, and research staff perceptions of an ...
Tejan Baldeh +8 more
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How are progression decisions made following external randomised pilot trials? A qualitative interview study and framework analysis [PDF]
Trials, 2022 Background External randomised pilot trials help researchers decide whether, and how, to do a future definitive randomised trial. The progression criteria are often prespecified to inform the interpretation of pilot trial findings and subsequent ...
Katie Mellor +3 more
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A randomised controlled trial is not a pilot trial simply because it uses a surrogate endpoint [PDF]
Pilot and Feasibility Studies, 2018 Background It has been argued that true endpoints (or ‘hard’ endpoints) for clinical trials, which are meaningful to clinicians, researchers and patients alike, are limited to those that measure health status, survival and cost.
M. J. Campbell +2 more
doaj +5 more sources
The reporting of progression criteria in protocols of pilot trials designed to assess the feasibility of main trials is insufficient: a meta-epidemiological study [PDF]
Pilot and Feasibility Studies, 2019 Introduction Pilot and feasibility trials are conducted to determine feasibility or to collect information that would inform the design of a larger definitive trial.
Lawrence Mbuagbaw +6 more
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Lignin-Containing Coatings for Packaging Materials-Pilot Trials. [PDF]
Polymers (Basel), 2021 One severe weakness of most biopolymers, in terms of their use as packaging materials, is their relatively high solubility in water. The addition of kraft lignin to starch coating formulations has been shown to reduce the water solubility of starch in dry coatings. However, lignin may also migrate into aqueous solutions.
Javed A +3 more
europepmc +5 more sources
Quality of abstracts of pilot trials in heart failure: A protocol for a systematic survey [PDF]
Contemporary Clinical Trials Communications, 2017 Introduction: Pilot trials are initial small-scale studies done to inform the design of larger trials. Their findings like other studies are usually disseminated as peer-reviewed journal articles.
Godsent Isiguzo +4 more
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Are pilot trials useful for predicting randomisation and attrition rates in definitive studies: A review of publicly funded trials. [PDF]
Clin Trials, 2018 BACKGROUND/AIMS: External pilot trials are recommended for testing the feasibility of main or confirmatory trials. However, there is little evidence that progress in external pilot trials actually predicts randomisation and attrition rates in the main ...
Cooper CL +4 more
europepmc +3 more sources
Introducing the CONSORT extension to pilot trials: enhancing the design, conduct and reporting of pilot or feasibility trials [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2018 This editorial provides a brief overview of the importance of pilot or feasibility trials or studies, the challenges with current practices in their conduct and reporting, an introduction to the Consolidated Standards of Reporting Trials (CONSORT ...
Luciana P. F. Abbade +2 more
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Pilot trials in physical activity journals: a review of reporting and editorial policy [PDF]
Pilot and Feasibility Studies, 2018 Background Since the early 2000s, a number of publications in the medical literature have highlighted inadequacies in the design, conduct and reporting of pilot trials.
Elsie Horne +5 more
doaj +2 more sources