Results 111 to 120 of about 4,197,402 (332)

Ethnicity : UK colorectal cancer screening pilot : final report [PDF]

27. In summary, the overall evaluation of the UK Pilot has demonstrated that key parameters of test and programme performance observed in randomised studies of FOBt screening can be repeated in population-based pilot programmes.
Clay, Diane, Gumber, Anil, HASH(0x55aa091dfc20), Johnson, Mark R. D., O'Sullivan, I., Orbell, Sheina, Owen, David, Szczepura, Ala   +7 more
core  

Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg [PDF]

, 2007
Background: This paper describes the results of a feasibility study for a randomised controlled trial (RCT). Methods: Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN) expressed an interest in recruiting for this study.
Cox, Neil H., Meredith, Sarah, Nunn, Andrew, Reynolds, Nick, Savelyich, Boki S.P., Shipley, Debbie, Thomas, Kim S., UK Dermatology Clinical Trials Network (charity status), Williams, Hywel C.   +8 more
core   +1 more source

Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study

Trials, 2014
BackgroundExternal pilot or feasibility studies can be used to estimate key unknown parameters to inform the design of the definitive randomised controlled trial (RCT).
M. Teare, M. Dimairo, Neil Shephard, Alexandra Hayman, Amy L Whitehead, Stephen J. Walters   +5 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Defining feasibility and pilot studies in preparation for randomised controlled trials: using consensus methods and validation to develop a conceptual framework

Trials, 2015
Pilot and feasibility studies underpin much of current health related research, including randomised controlled trials. The number of reports in which authors describe their studies as pilot or feasibility studies is increasing.
S. Eldridge, C. Bond, M. Campbell, S. Hopewell, L. Thabane, G. Lancaster, Claire L. Coleman   +6 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Outdoor recreational activity experiences improve psychological wellbeing of military veterans with post-traumatic stress disorder: Positive findings from a pilot study and a randomised controlled trial.

PLoS ONE, 2020
Trial registrationThe authors confirm that all ongoing and related trials for this intervention are registered. The studies reported in this manuscript are registered as clinical trials at ISRCTN: Pilot ID- ISRCTN15325073 RCT ID- ISRCTN59395217.
Mark Wheeler, Nicholas R Cooper, Leanne Andrews, Jamie Hacker Hughes, Marie Juanchich, Tim Rakow, Sheina Orbell   +6 more
doaj   +1 more source

Effect of Tendon Vibration on Hemiparetic Arm Stability in Unstable Workspaces [PDF]

, 2015
Sensory stimulation of wrist musculature can enhance stability in the proximal arm and may be a useful therapy aimed at improving arm control post-stroke.
Conrad, Megan O., Gadhoke, Bani, Scheidt, Robert A., Schmit, Brian D.   +3 more
core   +4 more sources

Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back!

Pilot and Feasibility Studies, 2020
Background The current CONSORT guidelines for reporting pilot trials do not recommend hypothesis testing of clinical outcomes on the basis that a pilot trial is under-powered to detect such differences and this is the aim of the main trial.
Martyn Lewis, K. Bromley, Christopher J Sutton, G. McCray, Helen Lucy Myers, Gillian A Lancaster   +5 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source