Results 11 to 20 of about 4,197,402 (332)

Pilot trials in thrombosis: Purpose and pitfalls. [PDF]

Res Pract Thromb Haemost, 2018
Randomized controlled trials provide important evidence to guide clinical practice. These full-scale trials are expensive, time consuming and many are never successfully completed. Well conducted pilot studies help with full-scale trial design, assessment and optimization of feasibility, and can avoid the waste of resources associated with starting a ...
Ikesaka R, Langlois N, Carrier M, Kearon C, Le Gal G.   +4 more
europepmc   +5 more sources

Guidance for using pilot studies to inform the design of intervention trials with continuous outcomes [PDF]

Clinical Epidemiology, 2018
Melanie L Bell,1 Amy L Whitehead,2 Steven A Julious2 1Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA; 2Medical Statistics Group, Design, Trials and Statistics, School ...
Bell ML, Whitehead AL, Julious SA
doaj   +6 more sources

Guidance for conducting feasibility and pilot studies for implementation trials

Pilot and Feasibility Studies, 2020
Background Implementation trials aim to test the effects of implementation strategies on the adoption, integration or uptake of an evidence-based intervention within organisations or settings.
Nicole Pearson, Patti-Jean Naylor, Maureen C. Ashe, Maria Fernandez, Sze Lin Yoong, Luke Wolfenden   +5 more
doaj   +2 more sources

A guide to the reporting of protocols of pilot and feasibility trials

Pilot and Feasibility Studies, 2019
Publishing protocols of trials including protocols of pilot and feasibility trials—designed to inform the designs of main trials—has been advocated as an important strategy towards improving transparency in the conduct and reporting of main trials and ...
Lehana Thabane, Gillian Lancaster
doaj   +2 more sources

Applying mixed methods to pilot feasibility studies to inform intervention trials

Pilot and Feasibility Studies, 2022
Background Pilot feasibility studies serve a uniquely important role in preparing for larger scale intervention trials by examining the feasibility and acceptability of interventions and the methods used to test them. Mixed methods (collecting, analyzing,
Kelly A. Aschbrenner, Gina Kruse, Joseph J. Gallo, Vicki L. Plano Clark   +3 more
doaj   +2 more sources

Dataset on travellers’ acceptance of border control technologies: Insights from METICOS pilot trialsPilot) supported by Zenodo [PDF]

Data in Brief
This paper presents a dataset from the METICOS11 https://meticos-project.eu/. project pilot trials related to the acceptance of border control technologies.
Sarang Shaikh, Sule Yildirim Yayilgan, Erjon Zoto, Mohamed Abomhara   +3 more
doaj   +2 more sources

Recommendations for progression criteria during external randomised pilot trial design, conduct, analysis and reporting

Pilot and Feasibility Studies, 2023
Background External randomised pilot trials aim to assess whether a future definitive Randomised Controlled Trial (RCT) is feasible. Prespecified progression criteria help guide the interpretation of pilot trial findings to decide whether, and how, a ...
Katie Mellor, Charlotte Albury, Susan J Dutton, Sandra Eldridge, Sally Hopewell   +4 more
doaj   +2 more sources

Findings of Sequential Pilot Trials of Aliviado Dementia Care to Inform an Embedded Pragmatic Clinical Trial. [PDF]

Gerontologist, 2022
BACKGROUND AND OBJECTIVES Many investigators of Alzheimer's disease and related dementias (AD/ADRD) are unfamiliar with the embedded pragmatic clinical trials (ePCTs) and the indispensable pilot phase preceding ePCTs.
Lin SY, Schneider CE, Bristol AA, Clancy M, Sprague SA, Aldridge M, Cortes T, Goldfeld KS, Kutner JS, Mitchell SL, Shega JW, Wu B, Zhu CW, Brody AA.   +13 more
europepmc   +2 more sources

Bayesian design and analysis of external pilot trials for complex interventions. [PDF]

Stat Med, 2021
External pilot trials of complex interventions are used to help determine if and how a confirmatory trial should be undertaken, providing estimates of parameters such as recruitment, retention, and adherence rates.
Wilson DT, Wason JMS, Brown J, Farrin AJ, Walwyn REA.   +4 more
europepmc   +3 more sources

Progression criteria in trials with an internal pilot: an audit of publicly funded randomised controlled trials

Trials, 2019
Background With millions of pounds spent annually on medical research in the UK, it is important that studies are spending funds wisely. Internal pilots offer the chance to stop a trial early if it becomes apparent that the study will not be able to ...
Esther Herbert, Steven A. Julious, Steve Goodacre   +2 more
doaj   +2 more sources