Results 21 to 30 of about 4,197,402 (332)

Pilot Trials in Clinical Research [PDF]

Circulation, 2009
Pilot trials are exploratory studies limited in size and scope that give insight into the actions, efficacy, and safety of a drug or device but cannot provide definitive support for specific mechanistic or therapeutic claims. Defined in this way, pilot trials have been used to guide clinical and translational research for many years. As studies defined
J. Loscalzo
openaire   +3 more sources

Status, reporting completeness and methodological quality of pilot randomised controlled trials in acupuncture: protocol for a systematic review

BMJ Open, 2021
Introduction To date, there has been a lack of knowledge about the status, reporting completeness and methodological quality of pilot trials in the acupuncture field.
Jianqiao Fang, Yajun Zhang, Hantong Hu, Xiaoyu Li, Jiali Lou, Xiaofen He, Yongliang Jiang   +6 more
doaj   +1 more source

Pilot Trial Characteristics, Postpilot Design Modifications, and Feasibility of Full-Scale Trials

JAMA Network Open, 2023
Key Points Question What pilot trial characteristics and postpilot trial modifications are associated with improved feasibility in full-scale trials? Findings This cohort study analyzed 249 pilot and full-scale trial pairs.
Xiangji Ying, Stephan Ehrhardt
semanticscholar   +1 more source

OXYFINES Technique for Upgrading Zinc Containing Blast Furnace Sludge—Part 1: Pilot Trials

Metals, 2020
In the Swedish steel industry, much work is put on further increasing the recycling and use of residual materials. However, blast furnace sludge is one residual which currently, despite its valuable contents of iron and carbon, is put on landfill or long-
Katarina Lundkvist, Sara Rosendahl, Fredrik Nyman, Kristofer Bölke, Lennart Gustavsson, Daniel Söderström, Anita Wedholm   +6 more
doaj   +1 more source

Cord pilot trial: update to randomised trial protocol [PDF]

Trials, 2015
The Cord Pilot Trial aimed to assess the feasibility of conducting a large UK randomised trial to compare the effects of alternative polices for timing of cord clamping (immediate within 20 seconds or deferred after at least 2 minutes) for very preterm birth before 32 weeks gestation.
Bradshaw, Lucy E., Pushpa-Rajah, Angela, Dorling, Jon, Mitchell, Eleanor J., Duley, Lelia   +4 more
openaire   +4 more sources

Determining external randomised pilot trial feasibility in preparation for a definitive trial: a web-based survey of corresponding authors of external pilot trial publications

Trials, 2023
Background External randomised pilot trials aim to determine whether a future definitive randomised controlled trial (RCT) should be conducted, and if so, how.
Katie Mellor, Susan J. Dutton, Sally Hopewell   +2 more
doaj   +1 more source

Pilot and feasibility trials in traditional Chinese medicine: a literature review of current practice

Pilot and Feasibility Studies, 2020
Background The guidelines for pilot and feasibility studies were published in 2016. Little is known about the guideline adherence of TCM (traditional Chinese medicine) pilot trials or whether the guidelines can significantly enhance the quality of ...
Guowei Li, Darong Wu, Xuejiao Chen, Jie Zeng, Ziyi Li, Lehana Thabane   +5 more
doaj   +1 more source

Recruiting Participants into Pilot Trials: Techniques for Researchers with Shoestring Budgets. [PDF]

Calif J Health Promot, 2016
Limited research has focused on recruitment strategies for health promotion researchers conducting small-scale pilot studies. Such research is important because small studies often have limited funding streams and personnel resources.
Joseph RP, Keller C, Ainsworth BE.
europepmc   +2 more sources

Peritransplant eculizumab does not prevent delayed graft function in deceased donor kidney transplant recipients: Results of two randomized controlled pilot trials

American Journal of Transplantation, 2020
Animal models and observational human data indicate that complement, including C5a, pathogenically participates in ischemia reperfusion (IR) injury that manifests as delayed graft function (DGF) following deceased donor kidney transplantation.
B. Schröppel, E. Akalin, Mukta Baweja, R. Bloom, S. Florman, M. Goldstein, B. Haydel, D. Hricik, S. Kulkarni, M. Levine, A. Mehrotra, Anup M Patel, E. Poggio, L. Ratner, R. Shapiro, P. Heeger   +15 more
semanticscholar   +1 more source

Clinical trial metadata:Defining and extracting metadata on the design, conduct, results and costs of 125 randomised clinical trials funded by the National Institute for Health Research Health Technology Assessment programme [PDF]

, 2015
Background:  By 2011, the Health Technology Assessment (HTA) programme had published the results of over 100 trials with another 220 in progress. The aim of the project was to develop and pilot ‘metadata’ on clinical trials funded by the HTA programme.  
Cook, Andrew, Davidson, Peter, Milne, Ruairidh, Raftery, James, Stanton, Louise, Turner, David, Young, Amanda   +6 more
core   +2 more sources