Results 41 to 50 of about 4,197,402 (332)

Identification and evaluation of risk of generalizability biases in pilot versus efficacy/effectiveness trials: a systematic review and meta-analysis

International Journal of Behavioral Nutrition and Physical Activity, 2020
Background Preliminary evaluations of behavioral interventions, referred to as pilot studies, predate the conduct of many large-scale efficacy/effectiveness trial.
M. Beets, R. Weaver, J. Ioannidis, M. Geraci, Keith Brazendale, Lindsay Decker, A. Okely, D. Lubans, E. V. van Sluijs, R. Jago, G. Turner-McGrievy, James F. Thrasher, Xiaming Li, A. Milat   +13 more
semanticscholar   +1 more source

The curious case of an internal pilot in a multicentre randomised trial—time for a rethink? [PDF]

, 2016
Multicentre randomised trials are complex projects with many operational uncertainties. The embedding of a formal check upon study progress and viability at a pre-specified time point (sometimes referred to as an 'internal pilot') is becoming ...
David John Beard, Graeme Stewart MacLennan, Johanna Rosemary Cook, Jonathan Alistair Cook   +3 more
core   +2 more sources

Process evaluation in practice based research networks: a study protocol for a mixed-methods implementation study

BMJ Open, 2023
Introduction General practitioners often criticise clinical trials for their poor applicability in primary care, which may at least partially explain why their engagement in primary care research remains limited. In order to enhance primary care research,
, Ildikó Gágyor, Tobias Dreischulte, Larissa Burggraf, Thomas Kühlein, Marco Roos, Jochen Gensichen, Peter Konstantin Kurotschka, Linda Sanftenberg, Helena Kosub, Annette Härdtlein, Stefanie Eck   +11 more
doaj   +1 more source

Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials. [PDF]

, 2014
BackgroundInhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants.
Ambalavanan, Namasivayam, Bara, Rebecca, Cotten, C Michael, Das, Abhik, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Garg, Meena, Higgins, Rosemary D, Keszler, Martin, Klein, Jonathan M, Lakshminrusimha, Satyan, Malian, Monica, Nelin, Leif D, Ohls, Robin, Saha, Shampa, Sanchez, Pablo J, Shankaran, Seetha, Sood, Beena G, Van Meurs, Krisa P, Wallace, Dennis   +18 more
core   +2 more sources

Feasibility of Virtual Tablet-Based Group Exercise Among Older Adults in Siberia: Findings From Two Pilot Trials

JMIR mHealth and uHealth, 2018
Background Regular physical activity has a positive effect on physical health, well-being, and life satisfaction of older adults. However, engaging in regular physical activity can be challenging for the elderly population because of reduced mobility ...
S. Nikitina, D. Didino, Marcos Báez, F. Casati   +3 more
semanticscholar   +1 more source

A review of current practice in the design and assessment of internal pilots in UK NIHR clinical trials

Trials, 2019
Background Internal pilots provide useful information which can help to optimise the running of the main trial. Although some recommendations exist in the literature for the design of internal pilots, little is known about current practice in terms of ...
Anna Rosala-Hallas, Carrol Gamble, Jane Blazeby, Paula R. Williamson   +3 more
doaj   +1 more source

Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention

BMC Medical Research Methodology, 2020
Background Assessing benefits and harms of health interventions is resource-intensive and often requires feasibility and pilot trials followed by adequately powered randomised clinical trials. Data from feasibility and pilot trials are used to inform the
Ravinder Claire, Christian Gluud, Ivan Berlin, Tim Coleman, Jo Leonardi-Bee   +4 more
doaj   +1 more source

Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot):study protocol for a randomized controlled trial [PDF]

, 2014
Background: Parkinson’s disease is a common movement disorder affecting approximately 127,000 people in the UK, with an estimated two thirds having speech-related problems.
Brady, Marian C, Clarke, Carl, Dowling, Francis, Ives, Natalie, Jowett, Sue, Kelly, Debbie, Patel, Ramilla, Patel, Smitaa, Rick, Caroline, Roberts, Helen, Sackley, Catherine M, Sands, Gina, Smith, Christina H, Wheatley, Keith   +13 more
core   +9 more sources

Empirical progression criteria thresholds for feasibility outcomes in HIV clinical trials: a methodological study

Pilot and Feasibility Studies, 2023
Introduction Pilot and feasibility trials use predetermined thresholds for feasibility outcomes to decide if a larger trial is feasible. These thresholds may be derived from the literature, observational data, or clinical experience.
Lawrence Mbuagbaw, Lucy Huizhu Chen, Eunice Aluko, Maya Stevens-Uninsky, Akudo C. J. Eze-Onuorah, Michael Cristian Garcia, Larysa Stech, Tariq Atkin-Jones, Nadia Rehman, Amidu Raifu   +9 more
doaj   +1 more source

Comparison between audio and tactile systems for delivering simple navigational information to visually impaired pedestrians [PDF]

, 2007
Many of the current GPS (Global Positioning Systems) navigation aids use an audio method to deliver navigation information to the user. For the visually impaired person this method can be problematic.
Brunel University, Eric Billett, Franjo Cecelja, Humanware, Millar, S., Olinkha Gustafson-Pearce, Skinner, C., Spirkovska, L., Talknav, The Voice, World Health Organisation (Who)   +10 more
core   +1 more source