Results 51 to 60 of about 4,197,402 (332)
BMJ Open, 2021 Objectives Prespecified progression criteria can inform the decision to progress from an external randomised pilot trial to a definitive randomised controlled trial.
Lehana Thabane +9 more
doaj +1 more source
A tutorial on pilot studies: the what, why and how
BMC Medical Research Methodology, 2010 Pilot studies for phase III trials - which are comparative randomized trials designed to provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely performed in many clinical areas. Also commonly know as "feasibility"
Ismaila Afisi +9 more
doaj +1 more source
Pilot and Feasibility Studies, 2022 Background The last 20 years have seen a marked increase in the use of cluster randomised trials (CRTs) in schools to evaluate interventions for improving pupil health outcomes. Schools have limited resources and participating in full-scale trials can be
Kitty Parker +6 more
doaj +1 more source
BMJ Open, 2023 Introduction Randomised controlled trials (RCTs) with a placebo comparator are considered the gold standard study design when evaluating healthcare interventions. These are challenging to design and deliver in surgery.
Jane M Blazeby +6 more
doaj +1 more source
The iBRA (implant breast reconstruction evaluation) study: protocol for a prospective multi-centre cohort study to inform the feasibility, design and conduct of a pragmatic randomised clinical trial comparing new techniques of implant-based breast reconstruction. [PDF]
, 2016 BACKGROUND: Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure in the UK. The introduction of techniques to augment the subpectoral pocket has revolutionised the procedure, but there is a lack of high ...
Barnes, NL +17 more
core +5 more sources
Guidelines for Designing and Evaluating Feasibility Pilot Studies
Medical Care, 2021 Supplemental Digital Content is available in the text. Background: Pilot studies test the feasibility of methods and procedures to be used in larger-scale studies.
J. Teresi +3 more
semanticscholar +1 more source
, 2018 This report presents a brief description of the pilot applications that have been evaluated as well as an overview of the events where they have been demonstrated and evaluated.
Zervas, Panagiotis +4 more
openaire +1 more source
A pilot randomized controlled trial of deprescribing [PDF]
Therapeutic Advances in Drug Safety, 2011 Objective: Polypharmacy and adverse drug reactions are frequent and important among older people. Few clinical trials have evaluated systematic withdrawal of medications among older people. This small, open, study was conducted to determine the feasibility of a randomized controlled deprescribing trial. Methods: Ten volunteers living in the community
Christopher, Beer +4 more
openaire +2 more sources
Pilot Trial of Homebound Hematopoietic Cell Transplantation
Transplantation and Cellular Therapy, 2022 For eligible patients with multiple myeloma (MM) and amyloid light chain (AL) amyloidosis, high-dose chemotherapy and autologous hematopoietic cell transplantation (HCT) is a standard and widely used consolidation therapy. Autologous HCT requires specialized care at a transplantation center and investment from patients and caregivers.
Heather J. Landau +18 more
openaire +2 more sources
PLoS ONE, 2016 We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial.
S. Eldridge +6 more
semanticscholar +1 more source