Results 81 to 90 of about 4,197,402 (332)

Quality of pilot trial abstracts in heart failure is suboptimal: a systematic survey

Pilot and Feasibility Studies, 2018
Background Pilot trials are miniature researches carried out with the sole aim of acting as the precursor for larger more definitive studies. Abstracts are used to summarize and introduce the findings to the reading audience.
Godsent C. Isiguzo, Moleen Zunza, Maxwell Chirehwa, Bongani M. Mayosi, Lehana Thabane   +4 more
doaj   +1 more source

Role of feasibility and pilot studies in randomised controlled trials: a cross-sectional study

BMJ Open, 2018
Objectives To assess the value of pilot and feasibility studies to randomised controlled trials (RCTs) funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme.
A. Blatch-Jones, Wei Pek, E. Kirkpatrick, M. Ashton-Key   +3 more
semanticscholar   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

The statistical interpretation of pilot trials: should significance thresholds be reconsidered?

BMC Medical Research Methodology, 2014
BackgroundIn an evaluation of a new health technology, a pilot trial may be undertaken prior to a trial that makes a definitive assessment of benefit. The objective of pilot studies is to provide sufficient evidence that a larger definitive trial can be ...
Ellen C Lee, Amy L Whitehead, R. Jacques, S. Julious   +3 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

REporting quality of PilOt randomised controlled trials in surgery (REPORTS): a methodological survey protocol

BMJ Open
Introduction The aim of this methodological review is to evaluate the completeness of reporting of surgical pilot and feasibility randomised trials as per the Consolidated Standards of Reporting Trials (CONSORT) extension to randomised pilot and ...
Lehana Thabane, Mohit Bhandari, Sameer Parpia, Keean Nanji, Sophia Zhang, Alex Thabane, Tyler McKechnie, Tania Kazi, Austine Wang, Aristithes G Doumouras, Cagla Eskicioglu   +10 more
doaj   +1 more source

Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review

Frontiers in Oncology, 2023
BackgroundA growing number of lifestyle interventions are being developed to promote weight loss and adoption of a healthful lifestyles among breast cancer survivors; yet Black and Latina women remain underrepresented.PurposeWe performed a scoping review
Margaret S. Pichardo, Margaret S. Pichardo, Tara Sanft, Tara Sanft, Leah M. Ferrucci, Leah M. Ferrucci, Yaideliz M. Romero-Ramos, Brenda Cartmel, Brenda Cartmel, Maura Harrigan, Ana I. Velazquez, Oluwadamilola M. Fayanju, Eric P. Winer, Eric P. Winer, Melinda L. Irwin, Melinda L. Irwin   +15 more
doaj   +1 more source

Quality of reporting of pilot and feasibility cluster randomised trials: a systematic review

BMJ Open, 2017
Objectives To systematically review the quality of reporting of pilot and feasibility of cluster randomised trials (CRTs). In particular, to assess (1) the number of pilot CRTs conducted between 1 January 2011 and 31 December 2014, (2) whether objectives
C. Chan, C. Leyrat, S. Eldridge
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Questions asked and answered in pilot and feasibility randomized controlled trials

BMC Medical Research Methodology, 2011
Background In the last decade several authors have reviewed the features of pilot and feasibility studies and advised on the issues that should be addressed within them.
Weatherall Mark, Pickering Ruth M, Shanyinde Milensu   +2 more
doaj   +1 more source