Results 51 to 60 of about 810,715 (313)
, 2015 International audienceNew paradigms, languages, modeling, verification, testing approaches and new tools in the field of programming and software should be created in the next 10 years, whether to make life easier for designers and maintainers of ...
Collet, Philippe +3 more
core +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Physical scale modeling of single free head piles under lateral loading in cohesive soils
Ingeniería Investigación y Desarrollo, 2017 This paper presents the results of the small scale modeling of free head wood piles under horizontal loading in cohesive soils, tested in order to compare the results with analytical models proposed by various authors.
Edgar Leonardo Salamanca-Medina +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Edificio de viviendas y locales comerciales - Cádiz (España)
Informes de la Construccion, 1971 Este bloque de trece plantas, situado en una de las más importantes avenidas de la ciudad, contiene 28 viviendas, locales de comercio, oficinas y garaje.
L. Miquel, A. Viloria
doaj +1 more source
Identification of enviromental aspects and impacts, of pre pilotage excavated, through life cycle assessment methodology [PDF]
, 2015 El presente artículo, desarrolla la identificación de aspectos e impactos ambientales de una actividad predominante en la construcción de obras civiles, llamada pilotaje pre excavado.
Yory Gutiérrez, Angélica María
core
El mètode científic aplicat a la caiguda lliure [PDF]
, 2013 Partint de l'observació de la caiguda de diferents cossos, ens farem una sèrie de pregun-tes amb les que analitzarem el moviment i extraurem conclusions. Finalitzarem l'article calculant el valor d'aquesta acceleració utilitzant una gravació del moviment.
Marco, Ernest Arnau
core +2 more sources