Results 31 to 40 of about 4,262,721 (264)
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The soil seed bank in abandoned tropical pastures: source of regeneration or invasion?
We assessed the availability of both pioneer and non-native species in the soil seed bank of old-growth forest and recently abandoned pasture, to evaluate whether the soil seed bank in these pastures represents a source of regeneration of species from ...
Leonel López-Toledo +1 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Aim of the study: To evaluate how middle-aged active restoration plantations of native tree species contribute to the recovery of the tropical cloud forest in terms of vegetation structure, tree richness, species composition, and to shade-tolerance and ...
Rosa-Amelia Pedraza +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Adventization of coenofloras of the classes of pioneer vegetation in Ukraine
The article presents the results of an analysis of the alien fraction of coenofloras of the classes of pioneer vegetation of Ukraine. In plant communities of the newly formed ecotopes, 113 alien species of 32 families and 88 genera were identified.
Dubyna D.V. +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
CRESCIMENTO DO JATOBÁ E DE LEGUMINOSAS ARBÓREAS EM DIFERENTES ESPAÇAMENTOS, EM ÁREA DEGRADADA
The use of pioneer plants, mainly nitrogen-fixing leguminous trees, associated to the secondary and climax species, has been making possible good results in the land reclamation.
GERALDO RIBEIRO ZUBA JUNIOR +5 more
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