Results 191 to 200 of about 31,206 (230)
PIP<sub>2</sub> corrects an endothelial Piezo1 channelopathy. [PDF]
Proc Natl Acad Sci U S AHashad AM +4 more
europepmc +1 more source
Review of PIP2 in Cellular Signaling, Functions and Diseases [PDF]
International Journal of Molecular Sciences, 2020 Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion.
Kalpana Mandal
exaly +4 more sources
Optogenetic Control of PIP2 Interactions Shaping ENaC Activity
International Journal of Molecular Sciences, 2022 The activity of the epithelial Na+ Channel (ENaC) is strongly dependent on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 binds two distinct cationic clusters within the N termini of β- and γ-ENaC subunits (&beta ...
Crystal R Archer +2 more
exaly +2 more sources
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels [PDF]
FEBS Letters, 2001 Inwardly rectifying potassium channels require binding of phosphatidylinositol-4,5-bisphosphate (PIP2) for channel activity. Three independent sites (aa 175–206, aa 207–246, aa 324–365) were located in the C-terminal domain of Kir2.1 channels by assaying
Yoshihiro Kubo +2 more
exaly +2 more sources
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Cholesterol and PIP2 Modulation of BKCa Channels
2023Ca2+/voltage-gated, large conductance K+ channels (BKCa) are formed by homotetrameric association of α (slo1) subunits. Their activity, however, is suited to tissue-specific physiology largely due to their association with regulatory subunits (β and γ types), chaperone proteins, localized signaling, and the channel's lipid microenvironment.
Thirumalini, Vaithianathan +3 more
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Regulation of ThermoTRP Channels by PIP2 and Cholesterol
2023Transient receptor potential (TRP) ion channels are proteins that are expressed by diverse tissues and that play pivotal functions in physiology. These channels are polymodal and are activated by several stimuli. Among TRPs, some members of this family of channels respond to changes in ambient temperature and are known as thermoTRPs.
Tamara, Rosenbaum +1 more
openaire +2 more sources
Regulation of the actin cytoskeleton by PIP2 in cytokinesis
Biology of the Cell, 2006Cytokinesis is a sequential process that occurs in three phases: assembly of the cytokinetic apparatus, furrow progression and fission (abscission) of the newly formed daughter cells. The ingression of the cleavage furrow is dependent on the constriction of an equatorial actomyosin ring in many cell types.
Michael R, Logan, Craig A, Mandato
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PIP2 and cholesterol interplay in inflammation and atherosclerosis
The FASEB Journal, 2022Introduction Cholesterol accumulation in arterial macrophages leads to foam cell formation, Nlrp3 inflammasome activation, and IL‐1b release. Phosphatidylinositol 4, 5‐bisphosphate (PIP2) plays a role in the cholesterol efflux pathway and IL‐1b release.
Kailash Gulshan +7 more
openaire +1 more source
PIP2 and Talin Join Forces to Activate Integrin
The Journal of Physical Chemistry B, 2015Integrins are major players in cell adhesion and migration, and malfunctions in controlling their activity are associated with various diseases. Nevertheless, the details of integrin activation are not completely understood, and the role of lipids in the process is largely unknown. Herein, we show using atomistic molecular dynamics simulations that the
Adam Orłowski +6 more
openaire +3 more sources