Results 101 to 110 of about 1,281,940 (294)

Evaluation of a Tree-based Pipeline Optimization Tool for Automating Data Science

, 2016
As the field of data science continues to grow, there will be an ever-increasing demand for tools that make machine learning accessible to non-experts. In this paper, we introduce the concept of tree-based pipeline optimization for automating one of the ...
Banzhaf W., Bergstra J., Feurer M., Hastie T. J., Snoek J., Urbanowicz R. J.   +5 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

DeepFaceLab: A simple, flexible and extensible face swapping framework

, 2020
DeepFaceLab is an open-source deepfake system created by \textbf{iperov} for face swapping with more than 3,000 forks and 13,000 stars in Github: it provides an imperative and easy-to-use pipeline for people to use with no comprehensive understanding of ...
Chervoniy, Nikolay, Dpfks, Mr., Facenheim, Carl Shift, Gao, Daiheng, Jiang, Jian, Liu, Kunlin, Marangonda, Sugasa, Perov, Ivan, RP, Luis, Umé, Chris, Wu, Pingyu, Zhang, Sheng, Zhang, Weiming, Zhou, Bo   +13 more
core  

Data Fusion of Objects Using Techniques Such as Laser Scanning, Structured Light and Photogrammetry for Cultural Heritage Applications

, 2015
In this paper we present a semi-automatic 2D-3D local registration pipeline capable of coloring 3D models obtained from 3D scanners by using uncalibrated images.
A Gallo, AW Fitzgibbon, DG Lowe, F Bernardini, H Lensch, HH Ip, JH Zhu, K Ikeuchi, M Callieri, M Corsini, M Dellepiane, M Dellepiane, M Pollefeys, MA Fischler, N Snavely, N Snavely, NR Pal, P Musialski, S Arya, SK Naik, Y Furukawa   +20 more
core   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Automating biomedical data science through tree-based pipeline optimization

, 2016
Over the past decade, data science and machine learning has grown from a mysterious art form to a staple tool across a variety of fields in academia, business, and government.
Andrews, Peter C., Kidd, La Creis, Lavender, Nicole A., Moore, Jason H., Olson, Randal S., Urbanowicz, Ryan J.   +5 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

On the Hardware Implementation of Triangle Traversal Algorithms for Graphics Processing

, 2010
Current GPU architectures provide impressive processing rates in graphical applications because of their specialized graphics pipeline. However, little attention has been paid to the analysis and study of different hardware architectures to implement ...
Ituero Herrero, Pablo, López Barrio, Carlos Alberto, López Vallejo, Marisa, Royer del Barrio, Pablo   +3 more
core