Results 61 to 70 of about 421,671 (269)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Development status and thinking of oil and gas pipeline corrosion detection technology

open access: yesYou-qi chuyun, 2020
Regular internal and external detection on oil and gas pipelines is helpful for timely and accurate detection of pipeline corrosion defects, and to take appropriate maintenance and replacement measures and effectively reduce the occurrence probability of
Zhiping WU   +4 more
doaj   +1 more source

Optimal pigging scheme and residual water distribution law in the initial pigging of undulate pipelines

open access: yesYou-qi chuyun, 2021
Water accumulation in the low-lying areas of undulate pipelines will seriously threaten the operation of pipelines. Herein, the optimal pigging scheme for the initial pigging stage of the large undulate pipelines in mountainous areas was studied by test,
Hua GE   +6 more
doaj   +1 more source

The COPD Pipeline

open access: yesCOPD: Journal of Chronic Obstructive Pulmonary Disease, 2009
Smoking Cessation. Nabi Biopharmaceuticals has received a NIDA grant of $4+ million in partial support of the next and, one hopes, final phases of a possible nicotine conjugate vaccine.
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Performance improvement, renovation and application of RMG offtake and regulating device in gas transmission station

open access: yesYou-qi chuyun, 2020
RMG512 self-operated monitoring regulator, a key offtake device, has been widely used in China's gas transmission pipeline offtake stations. With the promotion of "centralized monitoring" production management mode in stations, higher requirements have ...
Lijun ZHONG   +7 more
doaj   +1 more source

Circulating temperature rise of compressor station caused by opening of anti-surge valve and its solution

open access: yesYou-qi chuyun, 2023
During the operation of the compressor station where the centralized air after-cooling mode is adopted, the uncooled hightemperature natural gas from the discharge of compressor enters the suction of compressor through the anti-surge pipeline after the ...
PU Bin, XU Lie, HE Pengfei, JIANG Sen
doaj   +1 more source

Pipeline vectorization [PDF]

open access: yesIEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2001
This paper presents pipeline vectorization, a method for synthesizing hardware pipelines based on software vectorizing compilers. The method improves efficiency and ease of development of hardware designs, particularly for users with little electronics design experience.
Markus Weinhardt, Wayne Luk
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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