Results 61 to 70 of about 451,040 (269)

High Consequence Area identification method based on high-resolution remote sensing images

You-qi chuyun, 2022
Presently, the High Consequence Areas (HCAs) are mainly identified according to Oil and gas pipeline integrity management specification (GB 32167－2015).
Yi LIU, Changchai HAN, Wangfa SU, Deming LI, Lei GUO, Jun LIU, Wei CUI, Jianping ZHANG   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Vibration diagnosis method of oil pump inlet and outlet pipes

You-qi chuyun, 2021
The vibration of oil pump set and its inlet and outlet pipes during their operation is one of the main threats to the safe and stable operation of pipeline. Herein, the source of excitation force and the vibration causes of pipeline system were analyzed,
Baisong LI, Jianfeng SU, Xing ZHANG, Xuegang DONG, Li GAO   +4 more
doaj   +1 more source

The ‘Leaky Pipeline′ [PDF]

Chemistry – A European Journal, 2016
Gender bias is widespread and needs to be acknowledged and addressed by the scientific community. In this Guest Editorial, M. Resmini, Professor of Materials Chemistry at the Queen Mary University of London, describes how supervisors can play an important role in addressing the ‘leaky pipeline′, namely, the progressive loss of capable women from STEM ...
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mothers of Pipelines

Electronic Notes in Theoretical Computer Science, 2007
AbstractWe present a method for pipeline verification using SMT solvers. It is based on a non-deterministic “mother pipeline” machine (MOP) that abstracts the instruction set architecture (ISA). The MOP vs. ISA correctness theorem splits naturally into a large number of simple subgoals.
Sava Krstic, Robert B. Jones, John O'Leary   +2 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Exploration and implementation of network security strategy for gas pipeline SCADA system: taking the China-Russia Eastern Gas Pipeline Project as an example

You-qi chuyun, 2020
For the intrinsic safety and reliable operation of the SCADA system network of gas pipeline stations and the implementation of laws and regulations such as the People's Republic of China cyber security law, the network security protection scheme was ...
Shibin ZHANG, Lidong JIA, Yixin WEI, Wei SHI, Jian WANG   +4 more
doaj   +1 more source