Results 91 to 100 of about 14,875 (278)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Problems of weld overlay of seating surfaces of pipe fitting and solutions

Advanced Engineering Research, 2019
Introduction. A problem of providing the necessary functions of pipe fitting for blockage, control, distribution of the working medium flows under the most adverse operating conditions of oil and gas pipelines associated with abrasive particles ...
S. S. Poloskov
doaj   +1 more source

INTEGRAL and Swift/XRT observations of IGR J19405-3016

, 2009
IGR J19405-3016 is reported in the 3rd IBIS catalog as being one of its lowest significance sources (~4.6 sigma under an exposure of about 371 ks).
Barthelmy, Barthelmy, Beckmann, Beckmann, Bird, Burrows, Chaty, D. F. Torres, Dickey, Gehrels, Gliozzi, J. M. Wang, J. Q. Ge, Lebrun, Lund, Mas-Hesse, Masetti, Masetti, Masetti, Masetti, Masetti, Masetti, Masetti, Morelli, Mushotzky, Nespoli, Roming, S. Zhang, T. P. Li, Ubertini, Vedrenne, Winkler, Y. P. Chen   +32 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

XMM and Chandra measurements of the AGN intrinsic absorption: dependence on luminosity and redshift

, 2006
We combine bright XMM data with the Chandra Deep Field South observations in order to explore the behavior of the intrinsic AGN absorption, as a function of redshift and luminosity.Our sample consists of 359 sources selected in the hard 2-8 keV band ...
A. Akylas, A. Georgakakis, Alexander, Ballantyne, Barger, Barger, Cash, Coleman, Comastri, Dickey, Downes, E. Hatziminaoglou, Fiore, Georgakakis, Georgakakis, Georgakakis, Georgantopoulos, Georgantopoulos, Giacconi, Gilli, Hasinger, Hatziminaoglou, I. Georgantopoulos, Kitsionas, Königl, La Franca, Lawrence, Maiolino, Mushotzky, Norman, Page, Perola, Piconcelli, Risaliti, S. Kitsionas, Simpson, Stocke, Stoughton, Szokoly, Treister, Ueda, Zheng   +41 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Polar Dust, Nuclear Obscuration and IR SED Diversity in Type-1 AGNs

, 2018
Despite the hypothesized similar face-on viewing angles, the infrared emission of type-1 AGNs has diverse spectral energy distribution (SED) shapes that deviate substantially from the well-characterized quasar templates. Motivated by the commonly-seen UV-
Lyu, Jianwei, Rieke, George H.
core   +1 more source