Results 61 to 70 of about 112,527 (314)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Method for detection of deformation stress of large-diameter and high-pressure pipeline under complex terrain

You-qi chuyun, 2020
China-Russia Eastern Gas Pipeline is characterized by ultra-large diameter, high grade steel (X80) and high pressure rating. It is located in the area with geologically active permafrost and semi-permafrost zones in the north, where is prone to ...
Yukun LI, Yuxing LI, Yu ZHANG, Peng LIU, Wenguang YU   +4 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Research progress of hydrogen compatibility testing methods and hydrogen embrittlement prevention measures for pipeline steel

You-qi chuyun, 2023
Understanding the causes of hydrogen embrittlement and its detrimental effects is essential for ensuring the integrity of pipeline steel. Various testing methods, including slow strain rate and fatigue life testing, are commonly employed to evaluate the ...
WANG Yuchen, WU Qian, LIU Huan, KANG Zetian   +3 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Development of X90 submerged-arc helical welded pipe with diameter of 1 524 mm

You-qi chuyun, 2020
The use of high pressure, large diameter and high steel grade pipelines for long-distance natural gas transportation have become an important development tendency in the pipeline industry. The application of X90 pipeline steel pipe can raise the pipeline
Yun LIU, Hui NIU, Aijun NIU, Hongbo ZHAO, Wei LIU   +4 more
doaj   +1 more source

On shakedown, ratchet and limit analysis of defective pipeline [PDF]

, 2012
In this study, the limit load, shakedown and ratchet limit of a defective pipeline subjected to constant internal pressure and a cyclic thermal gradient are analyzed.
Chen, Chen, Chen, Chen, Chen, Chen, Chen, Haofeng Chen, James Ure, Koiter, Mackenzie, Melan, Ponter, Seshadri, Staat, Tianbai Li, Vu, Weihang Chen   +17 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Stress corrosion cracking behavior of pipeline steel due to liquid ammonia with water and oxygen impurities

You-qi chuyun
ObjectiveClassified as a high-strength low-alloy steel, pipeline steel is suitable for large-scale, long-distance pipeline transportation of liquid ammonia.
Jiaqing LI, Huilong LIANG, Zhiyu FENG, Pengbo YIN, Lin TENG, Zhuwu ZHANG, Yu LUO, Lilong JIANG   +7 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source