Results 61 to 70 of about 272,081 (336)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

System of automated monitoring and forecasting of the remaining resource of pipeline transport

Известия высших учебных заведений: Проблемы энергетики
This article presents a system of automated monitoring and forecasting of the residual resource of pipeline transport, consisting of a developed and manufactured information and diagnostic complex for monitoring the technical condition of pipeline ...
S. O. Gaponenko, А. E. Kondratiev, M. V.. Kalinina, R. V. Akhmetova   +3 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Protected Zones and Minimum Distances to Main Oil Pipelines (Petroleum Product Pipelines): The Concept, Legal Regime and Meaning for Secure Operation of Main Pipeline Transport Facilities [PDF]

, 2023
Yury A. Kapul
openalex   +1 more source

Melt-Mixing by Novel Pitched-Tip Kneading Disks in a Co-Rotating Twin-Screw Extruder

, 2010
Melt-mixing in twin-screw extruders is a key process in the development of polymer composites. Quantifying the mixing performance of kneading elements based on their internal physical processes is a challenging problem.
Alsteens, Booy, Bravo, Bravo, Brooks, Cheng, Cheng, Cross, Eiji Takeda, Funatsu, Hideki Tomiyama, Ishikawa, Ishikawa, Ishikawa, Ishikawa, Jaffer, Kajiwara, Kalyon, Lawal, Lawal, Levenspiel, Malik, Marchal, Ott, Ottino, Takashi Shigeishi, Toshihisa Kajiwara, Yang, Yao, Yasuya Nakayama, Yoshinaga, Zhang, Zienkiewicz   +32 more
core   +1 more source

Technical and Economic Characteristics of a CO2 Transmission Pipeline Infrastructure [PDF]

, 2010
Carbon capture and storage is considered one of the most promising technological options for the mitigation of CO2 emissions from the power generation sector and other carbon-intensive industries that can bridge the transition period between the current ...
CORREIA SERPA DOS SANTOS JOANA, MORBEE JORIS, TZIMAS Evangelos   +2 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On the Multidisciplinary Approach to the Analysis and Prediction of Operational Damageability and the Life of Linear Sections of the Oil Pipeline from the Position of Tribo-Fatigue

Механика машин, механизмов и материалов, 2017
This is a review and staging paper on the fundamental problem of “oil pipeline”. An algorithm of its possible complex solution from the positions of tribo-fatigue is proposed and briefly analyzed. In the first approximation, this algorithm is concretized.
Leonid A. Sosnovskiy, Yuriy V. Lisin, Andrei N. Kozik   +2 more
doaj  

Airships for transporting highly volatile commodities [PDF]

, 1975
Large airships may prove feasible as carriers of commodities that move as gases or cryogenic liquids; buoyant gaseous cargo could be ballasted with liquid cargo.
Sonstegaard, M.
core   +1 more source