Results 71 to 80 of about 272,081 (336)

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Hydrocarbons pipeline transportation risk assessment

open access: yesJournal of Physics: Conference Series, 2018
The pipeline transportation applying risks assessment issue in the arctic conditions is addressed in the paper. Pipeline quality characteristics in the given environment has been assessed. To achieve the stated objective, the pipelines mathematical model was designed and visualized by using the software product SOLIDWORKS.
A V Zanin, A A Milke, I N Kvasov
openaire   +1 more source

A hybrid Delphi-SWOT paradigm for oil and gas pipeline strategic planning in Caspian Sea basin [PDF]

open access: yes, 2012
The Caspian Sea basin holds large quantities of both oil and natural gas that could help meet the increasing global demand for energy resources. Consequently, the oil and gas potential of the region has attracted the attention of the international oil ...
Behzadian, Majid   +4 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Filling of recovered mining areas using solidifying backfill [PDF]

open access: yesActa Montanistica Slovaca, 2001
The aim of this article is to explore the possibilities for filling recovered mining areas using solidifying backfill .The article describes the preparation of the backfill (backfill formulation with an eventual application using low quality sands ...
Zeman Róbert, Šofranko Marián
doaj  

Prospects for coal slurry pipelines in California [PDF]

open access: yes
The coal slurry pipeline segment of the transport industry is emerging in the United States. If accepted it will play a vital role in meeting America's urgent energy requirements without public subsidy, tax relief, or federal grants.
Lynch, J. F.
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Energy-efficient gas pipeline transportation

open access: yesSystems Science & Control Engineering, 2014
Gas transportation via long pipelines is considered. Distributed parameter, dynamic modelling with series and shunt energy dissipation and gas stream, equivalent capacitance and inductance effects are proposed. Hybrid analysis techniques, wherein both the distributed and the lumped, concentrated elements of the pipeline system are included in the ...
R. Whalley, A. Abdul-Ameer
openaire   +1 more source

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