Results 81 to 90 of about 272,081 (336)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Nodal prices, capacity valuation and investments in natural gas markets - Overview and Analytical Framework [PDF]

open access: yes
Especially in the short-term, prices in natural gas markets are not exclusively determined by overall supply and demand, but also by the availability of the transport infrastructure.
Lochner, Stefan
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Optimization of Pipelines Transporting Solids

open access: yesJournal of the Pipeline Division, 1968
A method is presented for optimizing an economic model of a nonclosed network of pipelines transporting mixtures of wood chips and water. A cost function for a single pipe is developed as a polynomial expression in terms of the concentration of solids, C, and the pipe diameter, D. The characteristic response surface generated by this polynomial provide
William A. Hunt, Irving C. Hoffman
openaire   +2 more sources

Keystone XL Pipeline Project: Key Issues [PDF]

open access: yes, 2012
[Excerpt] This report describes the Keystone XL Project as it is proposed in the 2012 Presidential Permit application and the process that the State Department is obligated to complete to issue or deny that application. To the extent that they may affect
Luther, Linda   +3 more
core   +5 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Використання електроприводних ГПА - джерело зниження енерговитратності магістрального транспортування газу [PDF]

open access: yes, 2010
Обґрунтовано необхідність використання енергоефективних методів експлуатації трубопровідного транспорту газу. Проаналізовано вплив на енергозатратність магістрального транспортування газу структури витрат на споживання енергоресурсів, зміни ціни на ...
Мілевська, В. І.
core  

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez   +12 more
wiley   +1 more source

Perencanaan Dengan Horizontal Directional Drilling (Hdd) Untuk Memasang Pipeline Dibawah Sungai Kalimas [PDF]

open access: yes, 2013
Supply of aviation fuel to the pile tank in DPPU Juanda still done by bridger/Skid-Truck, where the distance delivery of aviation fuel from ISG Tj. Perak - DPPU Juanda carried through as far as 35 km.
Hariyanto, H. (Hariyanto)   +1 more
core  

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