Results 181 to 190 of about 32,648 (266)

Guineenoside B a triterpenoid saponin from Piper guineense (Piperaceae) triggers apoptosis and PI3K/Akt/mTOR inactivation and inhibits metastasis. [PDF]

BMC Complement Med Ther
Kamto ELD, Offermann A, Noté OP, Mbing JN, Haddad M, Pegnyemb DE, Njamen D, Bonnet SL, Perner S, Zingue S.   +9 more
europepmc   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Unveiling the Leishmanicidal Mechanism of 4-Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum. [PDF]

Chem Biodivers
Lorenzetti FB, Balbinot RB, Lazarin-Bidóia D, Faiões VDS, Torres-Santos EC, Nakamura CV, Ueda-Nakamura T, Garcia Cortez DA, Dias Filho BP.   +8 more
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Hydrogeochemical processes and water quality of the Aïn Taga Karst Spring, Tlemcen, Northwestern Algeria. [PDF]

Environ Geochem Health
Guettaia S, Boudjema A, Derdour A, Laoufi A, Ahmed AA, Almalki AS, Arafat AA, Ghoneim SSM.   +7 more
europepmc   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Anthelminthic Activity of <i>Piper nigrum</i>, <i>Albizia ferruginea</i>, and <i>Guarea cedrata</i> Against <i>Caenorhabditis elegans</i> and <i>Heligmosomoides polygyrus</i>: In Vitro and In Silico Molecular Docking Approach. [PDF]

Scientifica (Cairo)
Christelle Nadia NA, Cédric Y, Alain DC, Corine Leader ND, Besati M, Yaghoobi M, Liu W, Liu Y, Hu H.   +8 more
europepmc   +1 more source

Engineering and Characterization of a Fluorescent Fission Yeast Arp2/3 Complex for Single Molecule Mechanistic Investigations

Cytoskeleton, EarlyView.
ABSTRACT Arp2/3 complex is a seven‐component protein complex that facilitates the assembly of branched actin filament networks by binding to pre‐existing “mother” actin filaments and initiating the nucleation of new branched “daughter” filaments. Arp2/3 complex must be activated by a nucleation promoting factor such as the WASP/Scar protein family. The
Caitlin A. Anderson, Meghan E. O'Connell, Kaitlin E. Homa, Cristian Suarez, Michael L. James, Kashmeera D. Baboolall, Vilmos Zsolnay, Vladimir Sirotkin, David R. Kovar   +8 more
wiley   +1 more source

Rowing through recovery: Psychophysical outcomes of a combined 12-week rowing and exercise program in breast cancer survivors. [PDF]

Support Care Cancer
Del Rosario Asensio-Garcia M, Hernández-Sanchez S, Poveda-Pagan EJ, Nouni-Garcia R, Segura-Heras JV, Tomas-Rodriguez MI.   +5 more
europepmc   +1 more source