Results 11 to 20 of about 10,839 (205)

Calibration of transmission-dynamic infectious disease models: A scoping review and reporting framework. [PDF]

PLoS Computational Biology
Objective/backgroundTransmission-dynamic models are commonly used to study infectious disease epidemiology. Calibration involves identifying model parameter values that align model outputs with observed data or other evidence.
Emmanuelle A Dankwa, Léa Cavalli, Ruchita Balasubramanian, Melike Hazal Can, Hening Cui, Katherine M Jia, Yunfei Li, Sylvia K Ofori, Nicole A Swartwood, Carrie G Wade, Caroline O Buckee, Jeffrey W Imai-Eaton, Nicolas A Menzies   +12 more
doaj   +2 more sources

A Genetic Study of Spillovers in the Bean Common Mosaic Subgroup of Potyviruses [PDF]

Viruses
Nine viruses of the bean common mosaic virus subgroup of potyviruses are major international crop pathogens, but their phylogenetically closest relatives from non-crop plants have mostly been found only in SE Asia and Oceania, which is thus likely to be ...
Mohammad Hajizadeh, Karima Ben Mansour, Adrian J. Gibbs   +2 more
doaj   +2 more sources

Clinical, manometric, genetic, and histologic associations in pediatric intestinal pseudo-obstruction: A case series. [PDF]

J Pediatr Gastroenterol Nutr
Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Wolfson S, Butrviengpunt M, Tjaden N, Benitez AJ, Kota AS, Webster J, Kapavarapu P, Mousa H, Heuckeroth RO.   +8 more
europepmc   +2 more sources

Sugarcane Small Heat Shock Proteins Facilitate Sugarcane Mosaic Virus Replication via Interaction With the Movement Protein P3N-PIPO. [PDF]

Mol Plant Pathol
SCMV targets small heat shock proteins (ScHSP17.5 and ScHSP17.9A) via P3N‐PIPO to evade sugarcane immunity and enhance replication, revealing key host–virus interactions for breeding strategies. ABSTRACT Sugarcane mosaic virus (SCMV) causes substantial yield losses worldwide, yet the molecular basis underlying resistance and susceptibility in sugarcane
Yuan Y, Huang C, Akbar S, Huang Z, Yao W, Zhang M.   +5 more
europepmc   +2 more sources

Design of an energy efficient approximate BinDCT module in quantum cellular automata [PDF]

Scientific Reports
The quantum cellular automata (QCA) paradigm offers an ultra-low-power approach for realizing nanocomputing circuits at the molecular level, offering high parallelism capabilities.
Mohsen Vahabi, Ehsan Rahimi, Ali Newaz Bahar, Khan A. Wahid   +3 more
doaj   +2 more sources

International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease. [PDF]

Neurogastroenterol Motil
As an orphan disease, where treatment is not curative and diagnosis is often slow, VSCM represents a serious health and social problem requiring research efforts in several directions. ABSTRACT Background Visceral myopathy (VSCM) is an ultra‐rare life‐threatening condition characterized by severe impairment of gastrointestinal (GI), genitourinary, and ...
de Santa Barbara P, Ceccherini I, Heuckeroth RO, Di Lorenzo C, Alves MM, Beyder A, Borrelli O, Cacopardo L, Ceron R, Chen J, Chiappori F, Contessa A, De Giorgio R, Diamanti A, Faticato MG, Faure S, Hashmi SK, Huizinga JD, Kapur RP, Lambe C, Lancon L, McManigal R, Mousa H, Palmitelli A, Perreaux V, Prato AP, Pitto M, Proietti E, Rendu J, Rybak A, Sanders KM, Sardar S, Stanghellini V, Tambucci R, Thapar N, Vanden Berghe P, Vassalli M, Wang Q, Wangler M, Wolfson S, Zada A, Zhou J, Viti F.   +42 more
europepmc   +2 more sources

Pediatric intestinal pseudo-obstruction found in 3-year-old male with Rett-related mutation of methyl-CpG binding protein 2. [PDF]

JPGN Rep
Abstract A 3‐year‐old male with chronic abdominal distention, constipation, and severe malnutrition is diagnosed with pediatric intestinal pseudo‐obstruction (PIPO) after extensive evaluation that excluded mechanical, malabsorptive, metabolic, inflammatory, and infectious causes. Aside from speech delay, he has a normal neurologic exam.
Tran A, Patel-Sanchez N.
europepmc   +2 more sources

Integrated Proteomics and Transcriptomics Analyses Reveal the Transcriptional Slippage of a Bymovirus P3N-PIPO Gene Expressed from a PVX Vector in Nicotiana benthamiana

Viruses, 2021
P3N-PIPO (P3 N-terminal fused with Pretty Interesting Potyviridae ORF), the movement protein of potyviruses, is expressed as a translational fusion with the N-terminus of P3 in potyviruses.
Chulang Yu, Runpu Miao, Zhuangxin Ye, Stuart MacFarlane, Yuwen Lu, Junmin Li, Jian Yang, Fei Yan, Liangying Dai, Jianping Chen   +9 more
doaj   +1 more source

The P3N-PIPO Protein Encoded by Wheat Yellow Mosaic Virus Is a Pathogenicity Determinant and Promotes Its Pathogenicity through Interaction with NbRLK6 in Nicotiana benthamiana

Viruses, 2022
Similarly to other potyvirids, the bymovirus wheat yellow mosaic virus (WYMV) encodes a P3N-PIPO protein that is expressed by frameshifting occurring within the open reading frame of the P3 protein.
Runpu Miao, Zhuangxin Ye, Stuart MacFarlane, Yanjun Li, Qianzhuo Mao, Yanzhen Tian, Zhiping Deng, Zongtao Sun, Jian Yang, Junmin Li, Fei Yan, Jianping Chen, Chulang Yu   +12 more
doaj   +1 more source

Pipoxolan ameliorates cerebral ischemia via inhibition of neuronal apoptosis and intimal hyperplasia through attenuation of VSMC migration and modulation of matrix metalloproteinase-2/9 and Ras/MEK/ERK signaling pathways. [PDF]

PLoS ONE, 2013
Pipoxolan (PIPO) has anti-spasmodic effects, and it is used clinically to relieve smooth muscle spasms. Cerebrovascular disease is one of the leading causes of disability and death worldwide.
Yuh-Fung Chen, Huei-Yann Tsai, Kuo-Jen Wu, Lian-Ru Siao, W Gibson Wood   +4 more
doaj   +1 more source