Results 31 to 40 of about 376 (106)

Effect of point mutations on PipX levels.

, 2012
(A) Immunodetection of PipX from strains expressing wild type PipX (CS3X) and the indicated PipX point mutation derivatives (Y32A, E4A) alongside a pipX null strain (X-) using an Anti-PipX antibody.
Javier Espinosa (167607), Karim Boumediene Laichoubi (167604), Miguel Angel Castells (167609), Asunción Contreras (167611)   +3 more
core   +1 more source

Mutations at pipX suppress lethality of PII-deficient mutants of Synechococcus elongatus PCC 7942 [PDF]

, 2009
The PII proteins are found in all three domains of life as key integrators of signals reflecting the balance of nitrogen and carbon. Genetic inactivation of PII proteins is typically associated with severe growth defects or death.
Espinosa, Javier, Laichoubi, Karim Boumediene, Contreras, Asunción, Castells Rico, Miguel Ángel   +3 more
core   +1 more source

Localization of PipX residues discussed in this work. Details of interactions between one PipX monomer and P_II

, 2012
(A) or NtcA (B) are shown in the PII-PipX (PDB file 2XG8) and NtcA-PipX complexes (PDB file 2XKO). PipX structures are represented in blue ribbon while surface representation and pale colours are used for PII (subunits in grey, yellow and pink) and NtcA (
Javier Espinosa (167607), Karim Boumediene Laichoubi (167604), Miguel Angel Castells (167609), Asunción Contreras (167611)   +3 more
core   +1 more source

Sensory properties of the PII signalling protein family

The FEBS Journal, Volume 283, Issue 3, Page 425-437, February 2016., 2016
PII signaling proteins function as multitasking signal integrators to control cellular activities in response to the metabolite status. PII proteins bind adenylnucleotides, and when ATP is bound, they may interact with 2‐oxoglutarate (2‐OG). Glutamine signalling occurs either by post‐translational modification through glutamine‐dependent modifying ...
Karl Forchhammer, Jan Lüddecke
wiley   +1 more source

Predicting Glycerophosphoinositol Identities in Lipidomic Datasets Using VaLID (Visualization and Phospholipid Identification)—An Online Bioinformatic Search Engine

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
The capacity to predict and visualize all theoretically possible glycerophospholipid molecular identities present in lipidomic datasets is currently limited. To address this issue, we expanded the search‐engine and compositional databases of the online Visualization and Phospholipid Identification (VaLID) bioinformatic tool to include the ...
Graeme S. V. McDowell, Alexandre P. Blanchard, Graeme P. Taylor, Daniel Figeys, Stephen Fai, Steffany A. L. Bennett, Tao Huang   +6 more
wiley   +1 more source

Pediatric Investigation Plans for seizure and epilepsy treatments: An analysis since the implementation of the European Pediatric Regulation in 2006

Epilepsia, Volume 67, Issue 3, Page 1267-1283, March 2026.
Abstract Objective A Pediatric Investigation Plan (PIP) implemented under the European Pediatric Regulation (EC No. 1901/2006) aims to ensure early and systematic evaluation of medicines for children. We analyze PIPs for antiseizure medications (ASMs) submitted to the European Medicines Agency (EMA) since 2006, characterizing their content, focusing on
Valeria Agostini, Stéphane Auvin
wiley   +1 more source

rre37 Overexpression Alters Gene Expression Related to the Tricarboxylic Acid Cycle and Pyruvate Metabolism in Synechocystis sp. PCC 6803

The Scientific World Journal, Volume 2014, Issue 1, 2014., 2014
The tricarboxylic acid (TCA) cycle and pyruvate metabolism of cyanobacteria are unique and important from the perspectives of biology and biotechnology research. Rre37, a response regulator induced by nitrogen depletion, activates gene expression related to sugar catabolism.
Hiroko Iijima, Atsuko Watanabe, Junko Takanobu, Masami Yokota Hirai, Takashi Osanai, Anli Geng   +5 more
wiley   +1 more source

Effect of PipX substitutions in yeast two hybrid interaction signals.

, 2012
(A) An illustrative yeast two hybrid Interaction assay involving wild type PipX, PII, NtcA and NAGK proteins fused to either GAL4AD and GAL4BD. Photographs show growths on diploid media (CONTROL), on histidine (HIS3) and adenine (ADE2) minus media, and x-
Javier Espinosa (167607), Karim Boumediene Laichoubi (167604), Miguel Angel Castells (167609), Asunción Contreras (167611)   +3 more
core   +1 more source

Boosting Nanofiltration Membrane Selectivity via Amine‐Polymer Additive Engineering for Efficient Lithium Extraction From Brine

Advanced Science, Volume 13, Issue 3, 14 January 2026.
A diffusion‐controlled interfacial polymerization strategy incorporating poly(allylamine) (PAA) into piperazine (PIP) solution enables precise tuning of amine monomer diffusion and polyamide (PA) network formation with trimesoyl chloride (TMC). The resulting nanofiltration membranes exhibit crumpled morphology, appropriate surface charge, and enhanced ...
Shaofan Duan, Shuai Jiang, Ping Xu, Zhan Li, Pengfei Zhang, Yanyan Liu, Atsushi Matsuoka, Yuqing Lin, Jie Shen, Kecheng Guan, Tomohisa Yoshioka, Hideto Matsuyama   +11 more
wiley   +1 more source

Aktivierung eines Rezeptors sekundärer Botenstoffe durch allosterische Regulation eines dynamischen konformationellen Ensembles

Angewandte Chemie, Volume 137, Issue 38, September 15, 2025.
Intrinsisch ungeordnete Loops innerhalb globulärer Proteindomänen sind der Strukturbiologie lange Zeit entgangen. Söldner et al. zeigen hier, dass trotz dieser Unordnung durch die Bindung sekundärer Messenger in einem Rezeptor für eben diese Botenstoffe eine allosterische Modulation erfolgt.
Benedikt Söldner, Himanshu Singh, Elias Akoury, Gregor Witte, Rasmus Linser   +4 more
wiley   +1 more source