Results 31 to 40 of about 1,456 (263)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Intelligence on Threats—Municipal Management of Maritime Warnings in 15th-Century Catalonia
HistoriesSince the early 14th century, the Mediterranean coasts of the Crown of Aragon had mechanisms in place to alert populations of incoming threats from the sea. In addition to maritime surveillance systems strategically positioned at elevated vantage points,
Victòria A. Burguera i Puigserver
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Law, Crime, Morals, and Sense of Justice in Treasure Island
Oñati Socio-Legal Series, 2018 The aim of this article is to examine the legal, ethical and moral complications shown in Robert Louis Stevenson´s masterpiece, Treasure Island and the short story The Persons of the Tale.
Iker Nabaskues
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A PRELIMINARY STUDY ON A MIRROR OF JAPAN (RIBENYIJIAN)
Trans/Form/Ação, 2022 After the reign of Emperor Jiajing of the Ming Dynasty, as the problem of Japanese pirates became more and more serious, books devoted to the study of Japan began to be published.
Ji Ma, Jie Tong
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FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
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FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
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Pallas, 2009 The study of the world view propounded by Strabo in his Geography enables one to analyse the transformation of the concept of Mediterranean. Strabo’s work seems to complete the unification of Posidonius’s two worlds.
Katherine Clarke
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The Challenges of Prosecuting Maritime Pirates
Sriwijaya Law Review, 2020 Maritime piracy has always posed a constant threat to the peace and security of maritime navigation. The rise of acts of piracy is found to have been caused by several crucial factors such as geographical factor, weak law enforcement, maritime ...
Wan Siti Adibah Wan Dahalan +3 more
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
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