Results 51 to 60 of about 354,081 (248)

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Dynamic characteristic analysis of the piston pump with the valve plate outer dead center damage

AIP Advances
The piston pump is one of the key components of the hydraulic system. The valve plate, one of the key friction pairs of piston pumps, contributes most to the dynamical stability and operational reliability of the pump.
Zhaohui Bai, Ling Tang, Jinbo Wang, Yuanyuan Lv, Weidi Huang   +4 more
doaj   +1 more source

Remaining Useful Life Prediction of the Concrete Piston Based on Probability Statistics and Data Driven

Applied Sciences, 2021
This paper proposes a method on predicting the remaining useful life (RUL) of a concrete piston of a concrete pump truck based on probability statistics and data-driven approaches.
Jie Li, Yuejin Tan, Bingfeng Ge, Hua Zhao, Xin Lu   +4 more
doaj   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

UNSTEADY VELOCITY PIV MEASUREMENTS AND 3D NUMERICAL CALCULATION COMPATISONS INSIDE THE IMPELLER OF A RADIAL PUMP MODEL [PDF]

, 2013
PIV measurements were performed at mid hub section inside the impeller of a vaned diffuser pump model working with air. Several previous papers have already presented part of impeller flow characteristics mainly for vaneless diffuser and near nominal ...
PAVESI, Giorgio, DAZIN, Antoine, BOIS, Gérard, BAYEUL-LAINÉ, Annie-Claude, CAVAZZINI, Giovanna, DUPONT, Patrick   +5 more
core  

Data reduction problems using a 3 holes directional pressure probe to investigate mean flow characteristics in the vaneless gap between impeller and diffuser radial pump [PDF]

, 2013
Among several different measurement techniques that have been already performed and presented in a radial impeller pump model including PIV, a directional pressure probe has been used to obtain mean velocity field and stagnation pressure between impeller
DAZIN, Antoine, BOIS, Gérard, BAYEUL-LAINÉ, Annie-Claude, CHERDIEU, Patrick, DUPONT, Patrick   +4 more
core   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Axial Piston Pump Fault Diagnosis Method Based on Symmetrical Polar Coordinate Image and Fuzzy C-Means Clustering Algorithm

Shock and Vibration, 2021
In this paper, a fault diagnosis method based on symmetric polar coordinate image and Fuzzy C-Means clustering algorithm is proposed to solve the problem that the fault signal of axial piston pump is not intuitive under the time-domain waveform diagram ...
Wan-lu Jiang, Pei-yao Zhang, Man Li, Shu-qing Zhang   +3 more
doaj   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Effect of damping groove on flow dynamics and vibration characteristics of axial piston pump

AIP Advances, 2019
This paper presents pressure, flow and vibration characteristics of an axial piston pump valve plate with damping grooves. For flow ripple and vibration of the pump reduction, an improved compressible fluid model of axial-piston pump with damping groove ...
Tang Hesheng, Yan Ren, Jiawei Xiang, Cong Guo   +3 more
doaj   +1 more source