Results 351 to 360 of about 241,755 (405)
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A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Science, 1996Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was ...
Scott D. Feighner +31 more
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Clinical Endocrinology, 1976
SummaryIntrajugular administration of LHRH (0.6 and 1.2 μg) in hypophysectomized rats which received renal grafts of anterior pituitary induced a small but significant rise in plasma GH 5 and 10 min post‐treatment. LHRH, at the same dose levels, was ineffective in weight‐matched intact controls.
Panerai A. E. +5 more
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SummaryIntrajugular administration of LHRH (0.6 and 1.2 μg) in hypophysectomized rats which received renal grafts of anterior pituitary induced a small but significant rise in plasma GH 5 and 10 min post‐treatment. LHRH, at the same dose levels, was ineffective in weight‐matched intact controls.
Panerai A. E. +5 more
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Role of Monokines in Control of Anterior Pituitary Hormone Release
1990It has long been known that endogenous pyrogen, released as a result of injection of typhoid vaccine or in response to infection, produces fever and increases ACTH secretion. Recent studies have indicated that endogenous pyrogen is, at least in part, IL-1. This monokine has now been shown to activate the release of ACTH by a hypothalamic mechanism with
L. Milenkovic +4 more
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Molecular and Cellular Endocrinology, 1978
Abstract Cells dissociated from porcine pituitary glands have been used to examine the relationship between cyclic AMP levels and the stimulation of luteinising hormone (LH) secretion by luteinising hormone-releasing hormone (LHRH). It has been shown that while dibutyryl cyclic AMP and theophylline have a modest and, under some conditions, an ...
Ameae M. Walker, Colin R. Hopkins
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Abstract Cells dissociated from porcine pituitary glands have been used to examine the relationship between cyclic AMP levels and the stimulation of luteinising hormone (LH) secretion by luteinising hormone-releasing hormone (LHRH). It has been shown that while dibutyryl cyclic AMP and theophylline have a modest and, under some conditions, an ...
Ameae M. Walker, Colin R. Hopkins
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Journal of Clinical Endocrinology and Metabolism, 1983
A synthetic replicate of human pancreas growth hormone-releasing factor, hpGRF1-44-NH2, (hpGRF44), a 44-amino acid amidated peptide, was administered to seven normal men. In addition to placebo, 4 subjects received 3 doses of hpGRF44 (0.5 microgram/kg, 5
S. Rosenthal +4 more
semanticscholar +1 more source
A synthetic replicate of human pancreas growth hormone-releasing factor, hpGRF1-44-NH2, (hpGRF44), a 44-amino acid amidated peptide, was administered to seven normal men. In addition to placebo, 4 subjects received 3 doses of hpGRF44 (0.5 microgram/kg, 5
S. Rosenthal +4 more
semanticscholar +1 more source
Expert Opinion on Investigational Drugs, 2003
Growth hormone-releasing hormone (GHRH) regulates growth hormone release from the pituitary. However, in addition to this neuroendocrine action, much evidence implies an additional role for GHRH in carcinogenesis in non-pituitary tissues. This role of GHRH in cancer development appears to be due to the operation of several mechanisms, which involve the
Hippokratis Kiaris +3 more
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Growth hormone-releasing hormone (GHRH) regulates growth hormone release from the pituitary. However, in addition to this neuroendocrine action, much evidence implies an additional role for GHRH in carcinogenesis in non-pituitary tissues. This role of GHRH in cancer development appears to be due to the operation of several mechanisms, which involve the
Hippokratis Kiaris +3 more
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Journal of Endocrinology, 1976
SUMMARY Intravenous injections of synthetic LH-RH stimulated LH secretion in male dogs. Pretreatment with 50 μg oestradiol-17β, 60 or 165 min but not 15 min before LH-RH, inhibited LH secretion. Injection of 0·1–10 μg oestradiol 165 min before administration of LH-RH, blocked LH secretion. Basal plasma LH levels before LH-RH administration were
Gwyneth E. Jones, A. R. Boyns
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SUMMARY Intravenous injections of synthetic LH-RH stimulated LH secretion in male dogs. Pretreatment with 50 μg oestradiol-17β, 60 or 165 min but not 15 min before LH-RH, inhibited LH secretion. Injection of 0·1–10 μg oestradiol 165 min before administration of LH-RH, blocked LH secretion. Basal plasma LH levels before LH-RH administration were
Gwyneth E. Jones, A. R. Boyns
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Prostaglandins, 1975
The possibility that prostaglandin E2 (PGE2) may play a role in luteinizing hormone (LH) release was examined using an in vitro model. Addition of luteinizing hormone-releasing hormone (LH-RH) to the culture medium stimulated cyclic AMP accumulation and LH-release by incubated hemipituitaries, but did not affect the level of PGE2 or prostaglandin ...
Yitzhak Koch +3 more
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The possibility that prostaglandin E2 (PGE2) may play a role in luteinizing hormone (LH) release was examined using an in vitro model. Addition of luteinizing hormone-releasing hormone (LH-RH) to the culture medium stimulated cyclic AMP accumulation and LH-release by incubated hemipituitaries, but did not affect the level of PGE2 or prostaglandin ...
Yitzhak Koch +3 more
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Stimulation of growth hormone by luteinizing hormone-releasing hormone in active acromegaly.
Journal of Clinical Endocrinology and Metabolism, 1973Synthetic luteinizing hormone-releasing hormone was given to six patients (3 men and 3 women) with active acromegaly. All three men had rapid increases in growth hormone, as well as luteinizing and follicle-stimulating hormones.
Alan L. Rubin +5 more
semanticscholar +1 more source
The response of the pituitary gland to luteinizing hormone-releasing hormone in broody bantams
General and Comparative Endocrinology, 1981The concentration of plasma LH increased significantly (P < 0.001) after an iv injection of 20 μg LHRH/kg body wt in out-of-lay, laying, incubating, and brooding bantams. The increase in out-of-lay (2.6 ± 0.4 [SEM] ng/ml, n = 12) and laying (1.8 ± 0.3 ng/ml, n = 6) birds was significantly less (P < 0.05) than in incubating (5.0 ± 0.8 ng/ml, n = 10) or ...
Peter J. Sharp, Robert W. Lea
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