Results 91 to 100 of about 1,442,730 (143)

NBPF9 Gene May Be Involved in Congenital Hypopituitarism: A Whole-Genome Study of a Boy with Pituitary Stalk Interruption Syndrome and His Family

, 2020
Pituitary stalk interruption syndrome (PSIS) is a rare congenital defect manifesting as various degrees of anterior pituitary hormone deficiency. Scattered familial cases have been found, revealing some genetic variants.
Qing-Hua Guo, Cheng-Zhi Wang, Ling-Ling Guo, Yi-Ming Mu   +3 more
core   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Pituitary Stalk Interruption Syndrome from Infancy to Adulthood: Clinical, Hormonal, and Radiological Assessment According to the Initial Presentation. [PDF]

, 2015
Patients with pituitary stalk interruption syndrome (PSIS) are initially referred for hypoglycemia during the neonatal period or growth retardation during childhood. PSIS is either isolated (nonsyndromic) or associated with extra-pituitary malformations (
Catherine Pienkowski, Isabelle Oliver, Jean-Pierre Salles, Zeina Ajaltouni, Béatrice Jouret, Audrey Cartault, Thomas Edouard, Gwenaelle Diene, Charline Zadro, Annick Sevely, Céline Bar, Maithé Tauber, Bar Céline, Ajaltouni Zeina, Cartault Audrey, Zadro Charline, Edouard Thomas, Tauber Maithé, Oliver Isabelle, Sevely Annick, Pienkowski Catherine, Salles Jean-Pierre, Diene Gwenaelle, Jouret Béatrice   +23 more
core   +1 more source

Vitamin D in children with growth hormone deficiency due to pituitary stalk interruption syndrome

BMC Pediatrics, 2018
Background Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). The objective of this study was to assess vitamin D status in children with GH deficiency due to pituitary stalk
Cécile Delecroix, Raja Brauner, Jean-Claude Souberbielle   +2 more
doaj   +1 more source

Identification of Novel Interacting Proteins of FUZ and GPR161

PROTEOMICS, Volume 26, Issue 11, Page 64-74, November 2026.
ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar, Anna Battenhouse, Andrew J. Kim, Sung‐Eun Kim   +3 more
wiley   +1 more source

The use of deidentified organ donor testes for research

Andrology, Volume 14, Issue 8, Page 2359-2372, November 2026.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Pituitary stalk interruption syndrome: Cause, clinical manifestations, diagnosis, and management

, 2016
Purpose of review Pituitary stalk interruption syndrome (PSIS) is characterized by a thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic neurohypophysis.
Dacou-Voutetakis, C., Sertedaki, A., Voutetakis, A.   +2 more
core  

Trio-based whole exome sequencing in patients with ectopic posterior pituitary

Frontiers in Pediatrics
IntroductionEctopic posterior pituitary (EPP) is a rare congenital abnormality, sometimes associated with other midline defects, such as pituitary stalk interruption syndrome (PSIS), in which thin or absent pituitary stalk and anterior pituitary ...
Arthur Lyra, Itatiana Ferreira Rodart, Lara Barros, Tatiane Sousa e Silva, Antônio José da Rocha, Cristiane Kochi, Carlos Alberto Longui   +6 more
doaj   +1 more source

Pituitary stalk interruption syndrome. [PDF]

Pan Afr Med J, 2023
Ousirimaneechai K, Snabboon T.
europepmc   +1 more source

Pituitary Stalk Interruption Syndrome and Isolated Pituitary Hypoplasia May Be Caused by Mutations in Holoprosencephaly-Related Genes

, 2013
Context: Holoprosencephaly (HPE) is a developmental defect characterized by wide phenotypic variability, ranging from minor midline malformations (eg, single central incisor) to severe deformities.
Voutetakis, Antonis, Magiakou, Maria-Alexandra, Sertedaki, Amalia, Dacou-Voutetakis, Catherine, Tatsi, Christina, Kanaka-Gantenbein, Valavani, Eleni, Chrousos, George P., Christina   +8 more
core   +1 more source