International Journal of Endocrinology, 2020 Pituitary stalk interruption syndrome (PSIS) is a rare congenital defect manifesting as various degrees of anterior pituitary hormone deficiency. Scattered familial cases have been found, revealing some genetic variants.
Cheng-Zhi Wang +3 more
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Cholestasis Reveals Severe Cortisol Deficiency in Neonatal Pituitary Stalk Interruption Syndrome. [PDF]
PLoS ONE, 2016 Cholestasis has been reported during the course of congenital hypothalamic-pituitary deficiency, but crucial information is lacking regarding both its origin and prognosis. We aimed to characterize the course of cholestasis and factors contributing to it
Francois-Xavier Mauvais +4 more
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Pituitary stalk interruption syndrome is characterized by genetic heterogeneity.
PLoS ONE, 2020 Pituitary stalk interruption syndrome is a rare disorder characterized by an absent or ectopic posterior pituitary, interrupted pituitary stalk and anterior pituitary hypoplasia, as well as in some cases, a range of heterogeneous somatic anomalies.
Raja Brauner +3 more
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Pituitary Stalk Interruption Syndrome from Infancy to Adulthood: Clinical, Hormonal, and Radiological Assessment According to the Initial Presentation. [PDF]
PLoS ONE, 2015 Patients with pituitary stalk interruption syndrome (PSIS) are initially referred for hypoglycemia during the neonatal period or growth retardation during childhood. PSIS is either isolated (nonsyndromic) or associated with extra-pituitary malformations (
Céline Bar +11 more
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Pituitary stalk interruption syndrome in 53 postpubertal patients: factors influencing the heterogeneity of its presentation. [PDF]
PLoS ONE, 2013 BACKGROUND: Pituitary stalk interruption syndrome (PSIS) may induce an isolated growth hormone (GH) deficiency or multiple hypothalamic-pituitary (HP) deficiencies.
Luu-Ly Pham +4 more
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Pituitary stalk interruption syndrome: diagnostic delay and sensitivity of the auxological criteria of the growth hormone research society. [PDF]
PLoS ONE, 2011 OBJECTIVES: To study the diagnostic delay for pituitary stalk interruption syndrome (PSIS) with growth hormone deficiency (GHD) and the sensitivity of the auxological criteria of the Growth Hormone Research Society (GHRS) consensus guidelines. METHODS: A
Géraldine Gascoin-Lachambre +3 more
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Growth without growth hormone in combined pituitary hormone deficiency caused by pituitary stalk interruption syndrome [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2017 Growth hormone (GH) is an essential element for normal growth. However, reports of normal growth without GH have been made in patients who have undergone brain surgery for craniopharyngioma.
Sang Soo Lee +8 more
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Trio-based whole exome sequencing in patients with ectopic posterior pituitary [PDF]
Frontiers in PediatricsIntroductionEctopic posterior pituitary (EPP) is a rare congenital abnormality, sometimes associated with other midline defects, such as pituitary stalk interruption syndrome (PSIS), in which thin or absent pituitary stalk and anterior pituitary ...
Arthur Lyra +6 more
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Diagnosis of growth hormone (GH) deficiency: comparison of pituitary stalk interruption syndrome and transient GH deficiency [PDF]
BMC Pediatrics, 2009 Background Most patients with childhood non-organic growth hormone (GH) deficiency (GHD) produce a normal GH peak as young adults. Our objectives were to better define this transient GHD and evaluate the factors influencing the growth response of ...
Brauner Raja +4 more
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Risk factors and prediction model of metabolic disorders in adult patients with pituitary stalk interruption syndrome [PDF]
Scientific ReportsPituitary stalk interruption syndrome (PSIS) is an infrequently occurring congenital condition, and there exists a dearth of systematic investigative work focusing on the clinical features and long-term outcomes in adult patients.
Deyue Jiang +6 more
doaj +2 more sources