Results 81 to 90 of about 1,226,344 (298)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

CMS Barrel Pixel Detector Overview [PDF]

, 2007
The pixel detector is the innermost tracking device of the CMS experiment at the LHC. It is built from two independent sub devices, the pixel barrel and the end disks. The barrel consists of three concentric layers around the beam pipe with mean radii of
B. Meier, Broennimann, Ch. Hörmann, D. Kotlinski, H.Chr. Kästli, K. Gabathuler, Kotlinski, Kästli, P. Robmann, R. Horisberger, S. König, S. Streuli, T. Rohe, W. Bertl, W. Erdmann   +14 more
core   +2 more sources

Guided Super-Resolution As Pixel-to-Pixel Transformation [PDF]

2019 IEEE/CVF International Conference on Computer Vision (ICCV), 2019
Guided super-resolution is a unifying framework for several computer vision tasks where the inputs are a low-resolution source image of some target quantity (e.g., perspective depth acquired with a time-of-flight camera) and a high-resolution guide image from a different domain (e.g., a grey-scale image from a conventional camera); and the target ...
de Lutio, Riccardo, D'Aronco, Stefano, Wegner, Jan Dirk, Schindler, Konrad   +3 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Label-free timing analysis of SiPM-based modularized detectors with physics-constrained deep learning

Machine Learning: Science and Technology, 2023
Pulse timing is an important topic in nuclear instrumentation, with far-reaching applications from high energy physics to radiation imaging. While high-speed analog-to-digital converters become more and more developed and accessible, their potential uses
Pengcheng Ai, Le Xiao, Zhi Deng, Yi Wang, Xiangming Sun, Guangming Huang, Dong Wang, Yulei Li, Xinchi Ran   +8 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Qualification Procedures of the CMS Pixel Barrel Modules

, 2005
The CMS pixel barrel system will consist of three layers built of about 800 modules. One module contains 66560 readout channels and the full pixel barrel system about 48 million channels.
Erdmann, W., Horisberger, R., Kaestli, H. Chr., Kotlinski, D., Langenegger, U., Meier, B., Rohe, T., Starodumov, A., Trueb, P.   +8 more
core   +2 more sources

Invisible Pixels Are Dead, Long Live Invisible Pixels! [PDF]

Proceedings of the 2018 Workshop on Privacy in the Electronic Society, 2018
Privacy has deteriorated in the world wide web ever since the 1990s. The tracking of browsing habits by different third-parties has been at the center of this deterioration. Web cookies and so-called web beacons have been the classical ways to implement third-party tracking. Due to the introduction of more sophisticated technical tracking solutions and
Ruohonen Jukka, Leppänen Ville
openaire   +3 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Real-time Analog Pixel-to-pixel Dynamic Frame Differencing with Memristive Sensing Circuits

, 2018
In this paper, we propose an analog pixel differencing circuit for differentiating pixels between frames directly from CMOS pixels. The analog information processing at sensor is a topic of growing appeal to develop edge AI devices.
James, Alex Pappachen, Krestinskaya, Olga   +1 more
core   +1 more source