Results 251 to 260 of about 383,310 (333)

Optimizing Pichia Pastoris Cell‐Free Protein Synthesis to Improve Economics

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cell‐free protein synthesis (CFPS) is a powerful and versatile platform that supports a wide range of applications, from fundamental studies of the genetic code to scalable and rapid protein production. The recently developed Pichia pastoris CFPS combines advantages of both prokaryotic and eukaryotic systems, including a rapid growth rate ...
Rui Wu, Igor Koop, Gavin Murugan, Thagshanen Thillairajah, Karen M. Polizzi   +4 more
wiley   +1 more source

Primary Radiation Damage in a Strain-Engineering-Based SiGe/Si Heterostructure: A Molecular Dynamics Simulation. [PDF]

Nanomaterials (Basel)
Xing T, Liu S, Wang Q, Wang C, Wang Y, Adekoya MA, Wang X, Li X, Sheng H, Cai L, Tan J, Yi Y, Li Z.   +12 more
europepmc   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, EarlyView.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Mechanism of action of cisplatin on Na+/K+ ATPase of Caco-2 colon cells in vitro. [PDF]

PLoS One
Mourad R, Hodeify R, Kreydiyyeh S.
europepmc   +1 more source

Understanding cationic polyelectrolyte thermogels with varying charge densities toward biomaterials design

BMEMat, EarlyView.
Cationic polyurethane thermogels with customizable charge density were developed, exhibiting enhanced pH‐responsiveness. This work elucidates how cationic charges influence self‐assembly and thermogelling, providing insights for designing smart biomaterials.
Belynn Sim, Yi Jing Wong, Hamzah Kamaruddin, Qianyu Lin, Pablo Mota‐Santiago, Nigel Kirby, Alexis Lee, Yihao Leow, Alice Anhan Chen, Rubayn Goh, Xian Jun Loh   +10 more
wiley   +1 more source

Phosphodiesterase 8 regulation of excitation-contraction coupling as a target for cardiovascular disease: is it my turn now? [PDF]

Am J Physiol Heart Circ Physiol
Xu (许莹) Y, McConnell BK.
europepmc   +1 more source

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

BMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng, Xiaomin Luo, Peng Zhang, Chen Yang, Yuniel Ma, Xinhua Liu   +5 more
wiley   +1 more source

Genome-wide CRISPR Screening Reveals a PKA-Driven Resistance Mechanism to Metformin for Oral Cancer Prevention That Can Be Exploited by Combination with NSAIDs. [PDF]

Cancer Prev Res (Phila)
Hoang TS, Faraji F, Mendez-Molina AN, Adame-Garcia SR, Sato K, Ishikawa T, Vo PTT, Ramirez SI, Anguiano Quiroz PY, Guo T, Fan K, Wu X, Molinolo AA, Cohen EEW, Mali P, Lippman SM, Gutkind JS.   +16 more
europepmc   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source